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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Inhibition of integrin αVβ6 changes fibril thickness of stromal collagen in experimental carcinomas

Fig. 4

Ultrastructural analysis of KAT-4 and Capan-2 tumors using transmission electron microscopy. a Collagen fibril diameter in Capan-2 tumors treated with Fc:TβRII (3 × 10 mg/kg) (n = 5). Mean diameter was 48 nm in PBS-treated (n = 5) and 39 nm in 3G9-treated tumors (p < 0.01). b Collagen fibril diameter in Capan-2 tumors treated with 3G9 (3 × 10 mg/kg) (n = 5). No significant differences (p > 0.5) were observed in collagen fibril diameter after 3G9 treatment (mean diameter was approximately 49 nm in both phenotypes). c Collagen fibril diameter in Capan-2 tumors treated with 3G9 (5 × 10 mg/kg, extended protocol). Mean fibril diameter was 47 nm in PBS-treated and 41 nm in 3G9-treated tumors (p < 0.02). d Collagen fibril diameter in KAT-4 carcinomas treated with 3G9 (2 × 3 mg/kg) (n = 3). Mean fibril diameter was 43 nm in PBS-treated and 38 nm in 3G9-treated tumors (p = 0.02) (n = 3). Inserts show representative micrographs of collagen fibrils. To analyze fibril distribution, each data point (diameter for each fibril) was tabulated in GraphPad using the Frequency distribution analysis tool. Data was analyzed with Student’s t-test

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