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Table 1 Summary of the yeast two-hybrid results from previous publications [21, 22]

From: Peptides derived from the integrin β cytoplasmic tails inhibit angiogenesis

Name

Amino-acid sequence

β3-EN binding

β1CT:

-KLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

-(a)

β2CT:

-KALIHLSDLREYRRFEKEKLKSQWN-NDNPLFKSATTTVMNPKFAES

-

β3CT:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT(c)

+

β3CT-Δ762:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRG

+

β3CT-Δ761:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYR

+

β3CT-Δ760:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITY

+

β3CT-Δ759:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNIT

-

β3CT-Δ755:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTF

-

αIIb/β3CT:

-KVGFFKRNRPPLEEDDEEGQNITYRGT

-

β1/β3CT1:

-KLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNITYRGT

+

β1/β3CT2:

-KLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNITYEGK

+

β3/β1CT1:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNPKYEGK

-

β3/β1CT2:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNPKYRGT

-

β3CT-I/P:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNPTYRGT

-

β3CT-Y/F:

-KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITFRGT

+

Binding core:

 

xNITY(b)

  1. (a)The interactions between β3-endonexin (β3-EN) and the original and chimeric integrin β CTs were defined by arbitrary units (AU) of β-Galactosidase as described in the publications. (Positive interactions (+): AU > 5; negative interactions (−): AU < 5)
  2. (b)The “x” represented undetermined amino acids (number and residues)
  3. (c)Amino acids from the integrin β3 CT were shown in boldface
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Cell Communication and Signaling

ISSN: 1478-811X