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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Peptides derived from the integrin β cytoplasmic tails inhibit angiogenesis

Fig. 2

The mβCTPs selectively suppress blood vessel formation in implanted Matrigel plugs. a Aliquots of Matrigel liquid supplemented with the indicated mβCTPs (50 μM at a final concentration) were subcutaneously injected into BALB/c nude mice (n = 5) to form solid Matrigel plugs. Matrigel that did not contain peptides was used as a control. After 7 days, Matrigel plugs were carefully isolated and photographed. b Matrigel plugs were fixed and paraffin-embedded for histological analysis. Representative H&E staining images of the Matrigel plug sections were shown. Scale bar, 200 μm. c The amount of hemoglobin in Matrigel plugs was quantified by Drakin’s reagent. Results were expressed as means ± SD of five samples; statistical significance was analyzed using Student’s t test (*, p < 0.05; **, p < 0.01)

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