Fig. 1
From: Peptides derived from the integrin β cytoplasmic tails inhibit angiogenesis
The mβCTPs selectively inhibit HUVEC tube formation. a Amino-acid sequences of mβCTPs. In each of mβCTPs, a cell-penetrating peptide (CPP) was fused with a short amino-acid sequence from one of the C-termini of integrin β CTs (βCTP), comprising an NxxY/F motif and a proximal S/T cluster. b HUVECs were seeded on polymerized Matrigel with or without the indicated mβCTPs (20 μM at a final concentration) for 8 h. The formed capillary-like tube structures were recorded under an inverted microscope (5× objective). c The capillary-like polygon tubes were quantified. Results were expressed as means ±SD of three or more experiments, and statistical significance was analyzed using Student’s t test (**, p < 0.01)