Fig. 7From: In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itselfSchematic illustration of the impact of PTEN-Δ and PTEN on cellular processes. PTEN-Δ, as well as PTEN, inhibit AKT as antagonist of the PI3K and reduce the activity of MAPK JNK and p38. Both signaling pathways downstream result in a decrease of migration and adhesion and trigger apoptosisBack to article page