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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself

Fig. 6

Influence of PTEN-Δ and PTEN on cell signaling. Expression of integrin α1 (a), integrin α5 (b) integrin αV (c) and integrin β1 (d) in RCC cells were determined in PTEN-Δ and PTEN transfected cells by flow cytometry. Representative histograms are shown for each staining. Expression value is shown as percentage of expression of the pcDNA3 transfected control cells. Significance was calculated by Student‘s T-test, *p < 0.05. Phosphorylation of AKT (T308) (e), AKT (S473) (f), p38 (T180/Y182) (g) and JNK (T183/Y185) (h) in transfected 786-O and A498 cells was determined by Western blot. Representative Western blots are shown for each kinase. Activity value was determined by densitometric evaluation and is shown as percentage of activity of the pcDNA3 transfected cells. Significance was calculated by Student‘s T-test, *p < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X