Fig. 3
From: Emerging roles and regulation of MiT/TFE transcriptional factors
PKC triggered the transcriptional regulation of the TFEB-dependent autophagy-lysosome pathway. Under normal conditions, the PKC isoforms PKCα and PKCδ are inactivated. During hormone, neurotransmitter and bacterial lipopolysaccharide (LPS) stimulation, PKCα and PKCδ are activated, leading to their phosphorylation and inhibition of GSK3β, inhibiting the phosphorylation of TFEB serine sites needed for binding to cytoplasmic 14–3-3 proteins. TFEB nuclear translocation occurred and activated the expression of autophagy-lysosomal related genes. PKCδ activates JNK and P38, leading to the export of the repressor ZKSCAN3 from the nucleus to the cytoplasm,consequently alleviating transcriptional repression [74, 75]