Skip to main content

Table 1 List of the experimental determined structures of the extracellular domain of PD-1

From: The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD)

NO. PDBID Species Length Resolution (Å) R-value Notations Journal & Released date
1 1NPU mouse S34-L149(116) 2.0 0.198 C83S Immunity, 2004
2 3BIK mouse G30-I148(119) 2.65 0.211 C83S PNAS, 2008
3 3BP5 mouse S34-R147(114) 1.8 0.190 C83S PNAS, 2008
4 3BP6 mouse S34-T145(112) 1.6 0.184 C83S,A132L PNAS, 2008
5 3RNK mouse S34-T145(112) 1.74 0.195 C83S,A132L -, 2011
6 3SBW mouse S34-T145(112) 2.28 0.218 C83S,A132L -, 2011
7 3RNQ mouse S34-T145(112) 1.74 0.183 C83S, L128R -, 2011
8 3RRQ human N33-A149(117) 2.1 0.214 A132L,
E61 missing
D85-D92 missing
-, 2011
9 2M2D human M33-E150(118) NMR C93S, N33 M JBC, 2013
10 4ZQK human N33-E146(114) 2.45 0.207 C93S
D85-D92 missing
Structure, 2015
11 5B8C human S31-E146(116) 2.15 0.184 C93S
T59-E61 missing
Sci Rep, 2016
12 5GGR human S27-E146(120) 3.3 0.221 C93S
S73-N74missing
Nat Commun, 2016
13 5GGS human P31-E146(116) 2.0 0.179 C93S Nat Commun, 2016
14 5IUS Human D29-R147(119) 2.89 0.207 11 mutations # Structure, 2016
14 5JXE human N33-E146(114) 2.9 0.261 C93S
N58-E61 missing
A129-K131 missing
Cell Res, 2017
15 5WT9 human L25-L142 (118) 2.4 0.187 D85-C93 missing Nat Commun, 2017
  1. Note: # The PD-1 mutant contains 11 mutations, which are V64H, L65 V, N66 V, Y68H, M70E, N74G, K78 T, C93A, L122 V, A125V, A132I
\