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Table 1 List of the experimental determined structures of the extracellular domain of PD-1

From: The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD)

NO.

PDBID

Species

Length

Resolution (Å)

R-value

Notations

Journal & Released date

1

1NPU

mouse

S34-L149(116)

2.0

0.198

C83S

Immunity, 2004

2

3BIK

mouse

G30-I148(119)

2.65

0.211

C83S

PNAS, 2008

3

3BP5

mouse

S34-R147(114)

1.8

0.190

C83S

PNAS, 2008

4

3BP6

mouse

S34-T145(112)

1.6

0.184

C83S,A132L

PNAS, 2008

5

3RNK

mouse

S34-T145(112)

1.74

0.195

C83S,A132L

-, 2011

6

3SBW

mouse

S34-T145(112)

2.28

0.218

C83S,A132L

-, 2011

7

3RNQ

mouse

S34-T145(112)

1.74

0.183

C83S, L128R

-, 2011

8

3RRQ

human

N33-A149(117)

2.1

0.214

A132L,

E61 missing

D85-D92 missing

-, 2011

9

2M2D

human

M33-E150(118)

NMR

C93S, N33 M

JBC, 2013

10

4ZQK

human

N33-E146(114)

2.45

0.207

C93S

D85-D92 missing

Structure, 2015

11

5B8C

human

S31-E146(116)

2.15

0.184

C93S

T59-E61 missing

Sci Rep, 2016

12

5GGR

human

S27-E146(120)

3.3

0.221

C93S

S73-N74missing

Nat Commun, 2016

13

5GGS

human

P31-E146(116)

2.0

0.179

C93S

Nat Commun, 2016

14

5IUS

Human

D29-R147(119)

2.89

0.207

11 mutations #

Structure, 2016

14

5JXE

human

N33-E146(114)

2.9

0.261

C93S

N58-E61 missing

A129-K131 missing

Cell Res, 2017

15

5WT9

human

L25-L142 (118)

2.4

0.187

D85-C93 missing

Nat Commun, 2017

  1. Note: # The PD-1 mutant contains 11 mutations, which are V64H, L65 V, N66 V, Y68H, M70E, N74G, K78 T, C93A, L122 V, A125V, A132I