TY - JOUR AU - Du, Jiangfeng AU - Qin, Yaping AU - Wu, Yahong AU - Zhao, Wenshan AU - Zhai, Wenjie AU - Qi, Yuanming AU - Wang, Chuchu AU - Gao, Yanfeng PY - 2018 DA - 2018/06/07 TI - The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD) JO - Cell Communication and Signaling SP - 25 VL - 16 IS - 1 AB - Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fraction of cancer patients and the success makes PD-1 as a valuable target in immune checkpoint therapy. For the rational design of PD-1 targeting modulators, the ligand binding mechanism of PD-1 should be well understood in prior. SN - 1478-811X UR - https://doi.org/10.1186/s12964-018-0239-9 DO - 10.1186/s12964-018-0239-9 ID - Du2018 ER -