Casein kinase 1α: biological mechanisms and theranostic potential

Table 1 Substrates of human CK1α in major cell signaling pathways

Gene	Protein	Phosphorylation site	Pathway	Reference
APC	APC	S1504, S1505, S1507, S1510	Wnt/β-Catenin	[31]
CTNNB1	β-Catenin	S45		[5, 6]
CDH1	E-cadherin	S846		[33]
LRP6	LRP6	T1493		[34]
JADE1	JADE1	S18, S20		[36, 37]
FOXO3A	FOXO3A	S318, S321	Autophagy	[72]
DEPTOR	DEPTOR	S286, S287, S291		[74, 75]
SQSTM1	SQSTM1/p62	S349		[79]
BCL10	BCL10	N/A	NF-κB	[11, 260]
CARD11	CARMA1	S608		[11, 260]
MALT1	MALT1	N/A		[11, 260]
FADD	FADD	S194		[80, 86]
RELA	NF-κB/p65	S316		[261]
RIPK1	RIP1	a.a. 293–558		[83]
TNFRSF1A	TNFR1/p55	N/A		[83]
TNFRSF1B	TNFR2/p75	N/A		[84]
YBX1	YB-1	S176		[89]
CDC25A	CDC25A	S79, S82	Cell cycle	[92, 93]
MDM2	MDM2	N/A		[7, 95]
MDM4	MDMX	S289		[8, 9, 96]
MYC	c-Myc	S252		[94]
TP53	P53	S20		[97]
YWHAQ	14-3-3τ	S233		[101]
YWHAZ	14-3-3ζ	T233		[101]
BACE1	β-Secretase 1	S498	Alzheimer’s disease	[113]
KCNIP3	Calsenilin	S63	Alzheimer’s disease	[115]
CREB1	CREB	S108, S111, S114	Parkinson’s disease	[128]
LRRK2	PARK8	S910, S935, S955, S973		[131]
PARK2	Parkin	S101, S378		[132]
SNCA	α-Synuclein	S87, S129		[126]
CDK5	CDK5	S159		[134]