Fig. 2
From: Casein kinase 1α: biological mechanisms and theranostic potential
CK1α expression in normal human tissues and the most common human cancer tissues. a RNA sequencing data for CK1α expressed in normal human tissues are reported as median reads per kilobase per million mapped reads (RPKM). The data were generated by the Genotype-Tissue Expression project (www.gtexportal.org) and were first published in references [238, 239] and deposited in the HPA (www.proteinatlas.org). b Protein expression data from HPA (www.proteinatlas.org), first published in reference [240]. c RNA sequencing data of CK1α levels in 17 cancer types are reported as median number of fragments per kilobase of exon per million reads (FPKM), generated by The Cancer Genome Atlas (TCGA) (https://cancergenome.nih.gov/); data were first published in reference [241], and were deposited in the HPA (www.proteinatlas.org). d, e Microarray data of CK1α expression in normal and cancer tissues in humans were obtained from Oncomine (www.oncomine.org) (reference [242]). Differences in expression levels were evaluated with the Student’s t test using Oncomine software. d Upregulation of CK1α mRNA levels in human cancer tissues relative to matched normal tissues. a, Pancreas, b, pancreatic carcinoma (left, reference [243] and right, reference [244]); c, brain; d, anaplastic astrocytoma; e, oligodendroglioma; f, glioblastoma (reference [245]). e Downregulation of CK1α mRNA levels in human cancer tissues relative to matched normal tissues. g, CD4-positive (n = 5) + CD8-positive (n = 5) + normal T lymphocytes (n = 10); h, angioimmunoblastic T-cell lymphoma; i, anaplastic large cell lymphoma (reference [246]); j, esophagus; k, esophageal squamous cell carcinoma; l, esophageal adenocarcinoma (left, reference [247]; right, reference [248]); m, colon (n = 19) + rectum (n = 3); n, rectal adenocarcinoma; o, colon adenocarcinoma (data obtained from TCGA and deposited in Oncomine); p, bladder mucosa; q, infiltrating bladder urothelial carcinoma (reference [249]); r, buccal mucosa; s, head and neck squamous cell carcinoma (reference [250])