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Table 2 ZDOCK Score for Alpha, Beta and Gamma tubulins

From: Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6

Protein Name

SDS (k cal/mol)

SELEC (k cal/mol)

RMSD (Ã…)

Alpha Tubulin

−2.09

−2.73

1.45

Beta Tubulin

−3.14

−2.73

1.45

Gamma Tubulin

−2.87

0.10

1.55

  1. S DS indicates sum of Desolvation energy, S ELEC indicates sum of Electrostatic energy, RMSD Root Mean Square Deviation of C-alpha atoms in Angstroms units
  2. As the Desolvation and Electrostatic energy of Alpha tubulin is −2.09 and − 2.73 respectively (Range ≤ − 3 kcal/mol), followed by RMSD values which is 1.45 Å (Range ≤ 2.5 Å) for Alpha tubulin. This confirms a near native hit when compared to values of beta and gamma tubulin