Fig. 10
From: miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KIT
Downregulation of miR-148b-3p is correlated with high risk grades and poor survival for patients with GIST. (a) Relative miR-148b-3p expression levels were inversely correlated to tumor risk grade in a progressive manner. (b) Relative expression of miR-148-3p was significantly correlated with recurrent or metastatic GISTs. (c) High miR-148b-3p expression marks low OS for GIST patients. Kaplan-Meier analysis with the log-rank test for OS was performed for the 59 GIST patients whose samples were used in this work. (d) High miR-148b-3p expression is negatively related to disease-free survival for GIST patients. Kaplan-Meier analysis with the log-rank test for DFS was performed for the 59 GIST patients whose samples were used in this work. miRNAs expression was normalized to U6 expression. *P<0.05, **P<0.01