Skip to main content
Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis

Fig. 4

Wnt3a ligand enhances autophagy initiation in hippocampal neurons. a Wnt3a ligand enhanced autophagy initiation, promoting maturation from LC3I to LC3II at 37 °C for 60 min in hippocampal neurons. In parallel cultures, (b) dose-response curves for lithium (60 min) and (c) rapamycin (120 min) were used as controls, and both showed increased processing of LC3 in hippocampal neurons. The graphs show the ratio between the LC3II/LC3I fraction that was normalized to actin. The data are expressed as the mean ± S.E.M. of n = 3 independent experiments, *p < 0.05, **p < 0.001

Back to article page