TY - JOUR AU - Ríos, Juvenal A. AU - Godoy, Juan A. AU - Inestrosa, Nibaldo C. PY - 2018 DA - 2018/04/11 TI - Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis JO - Cell Communication and Signaling SP - 15 VL - 16 IS - 1 AB - In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonical pathways. In the canonical pathway, the binding of canonical ligands such as Wnt3a to the Frizzled receptor induces inactivation of glycogen synthase kinase-3β (GSK-3β), which stabilizes β-catenin and allows its translocation to the nucleus. However, to date, few studies have focused on β-catenin-independent Wnt signaling or explained the underlying mechanisms connecting Wnt signaling to cellular energy metabolism. A recent study demonstrated negative regulation of 5′ adenosine monophosphate-activated protein kinase (AMPK), a major target of GSK-3β that regulates cellular metabolism under diverse conditions. Mainly based on these observations, we evaluated whether Wnt3a ligand modulates autophagy by regulating the GSK-3β/AMPK axis. SN - 1478-811X UR - https://doi.org/10.1186/s12964-018-0227-0 DO - 10.1186/s12964-018-0227-0 ID - Ríos2018 ER -