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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Interaction between human osteosarcoma and mesenchymal stem cells via an interleukin-8 signaling loop in the tumor microenvironment

Fig. 7

Changes in the lung nodules and the expression of IL-8 and phosphorylated FAK in pulmonary metastatic lesions. a The group given nIL-8 Ab showed a significant suppression of the size of the pulmonary metastatic lesion. (*) p < 0.05. b Immunostaining of the tissues collected from the pulmonary metastatic lesion. Decreased expression of IL-8 and phosphorylation of FAK was observed in the group administered nIL-8 Ab. Original magnification, × 400; Scale bars: 50 μm. c The number of IL-8 and p-FAK positive cells per unit area. Data represents represent the mean ± SD of three independent experiments. p < 0.05 was considered to indicate significance: (*) p < 0.05, (**) p < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X