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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Interaction between human osteosarcoma and mesenchymal stem cells via an interleukin-8 signaling loop in the tumor microenvironment

Fig. 5

Effects of co-culture condition and administration of rIL-8 or anti-IL-8 Ab on motility of MG63. a The cell motility of MG63 was assessed in each group at 48 h after the challenge with or without rIL-8 and neutralizing anti-IL-8 antibodies (nIL-8 Ab). b The amount of MG63 cells that crossed the membrane was measured. A significant decrease in motility was found in the group given nIL-8 Ab. (*) p < 0.05, (**) p < 0.01. c The cell invasion in MG63 was assessed in each group after 48 h. d The amount of the cells of which the membrane with Matrigel was crossed by MG63 was measured. Decreased migration ability was found in the group administered anti-IL-8 Ab. (*) p < 0.05, (**) p < 0.01

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