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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1

Fig. 9

Schematic illustration of Ras enhancing TGF-β signaling through decreasing of SPSB1, a TβRII ubiquitination regulator. SPSB1 interacts with TβRII/TβRI (RII/RI), resulting in polyubiquitination and degradation of the type II receptor (black arrows). Ras interacts with SPSB1, resulting in its protein level decrease through mono-, di-ubiquitination of SPSB1 (green arrows). Consequentluy, Ras enhances TGF-β signaling

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Cell Communication and Signaling

ISSN: 1478-811X