Skip to main content
Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells

Fig. 6

ICG001 mediated activation of PTEN is PP2A dependent a Western blot analysis to show the effect of ICG001 and PP2A inhibitor Okadaic acid (OA) on PTEN phosphorylation. Results represent mean ±S.E from four independent experiments. (*p < 0.01, DMSO vs ICG001; #p < 0.05, ICG001 vs ICG001 + OA). b Western blot analysis showing Survivin expression in ICG001−/+ OA treated samples. Results represent mean ±S.E from four independent experiments. *p < 0.05 (DMSO vs ICG001 and ICG001 vs ICG001 + OA). c ICG001 activates PP2A in murine TICs. PP2Ac was immuno-pelleted from cell extracts and PP2A activity was measured using PP2A activity assay kit as described in material and methods. Results represent mean ±S.E from four independent experiments

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X