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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Utilization of adipocyte-derived lipids and enhanced intracellular trafficking of fatty acids contribute to breast cancer progression

Fig. 1

Lipid transfer during co-culture and co-cultivated breast cancer cells increased aggressiveness. a Lipid accumulation in cancer cells shown by Bodipy staining (lipids in green and nuclei in blue; scale bar, 50 μm), NC, non-co-culture; Coc, co-culture. b TG content in SK-BR-3 (left) and SUM159PT (right) cells cultured alone (NC) or with mature adipocytes (Coc) for 3 days. c Non-co-cultivated (NC) and co-cultivated (Coc) SK-BR-3 (left) and SUM159PT (right) cells migrated/invaded to the outer surface of the Transwell chamber; the migration times were 24 h and 6 h, respectively. Five fields were randomly taken for each chamber, and the representative migration images are shown. d Comparison of the proliferative ability of non-co-cultivated (NC) and co-cultivated (Coc) SUM159PT cells. Fold change comparison of the cell optical density during 48 h of SUM159PT cell non-co-cultivation (NC) or co-cultivation (Coc) with mature adipocytes for 3 days (n = 3). Representative results from at least three independent experiments are shown. *p < 0.05, **p < 0.01

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