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Table 2 Univariate and multivariate survival analyses of HMGB2 expression and overall survival for patients with breast cancer

From: HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer

Variable

Univariate analysis

Multivariate analysis

HR (95%CI)

P

HR (95%CI)

P

Age

1.022 (0.997–1.048)

0.090

 

NI

Tumor Diameter

3.748(1.829–7.681)

< 0.001

2.493(1.194–5.203)

0.015

Grade

1.955(1.346–2.840)

< 0.001

1.654(1.115–2.452)

0.012

Stage

2.991(1.790–4.999)

< 0.001

1.843(1.476–2.738)

0.026

Subtypes

1.206(0.952–1.528)

0.121

 

NI

ER Status

0.532(0.305–0.927)

0.026

0.814(0.459–1.444)

0.482

PR Status

1.003(0.578–1.740)

0.992

 

NI

HER-2/neu Status

1.055(0.530–2.102)

0.879

 

NI

HMGB2

4.372(2.059–9.280)

< 0.001

3.009 (1.393–6.500)

0.005

  1. NI: not included in multivariate survival analysis
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