Fig. 5From: HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancerHMGB2 is positively associated with cancer cell growth and the Warburg effect in vivo. MCF-7-scramble/MCF-7-shHMGB2 breast cancer cells were injected subcutaneously into the right or left forelimb of five nude mice (5 × 106 cells per sample for each mouse). Gross tumors in the mice (a), and tumor growth curves and weights (b) are shown. c Representative photographs of 18F–FDG PET/CT scans of MCF-7-scramble/MCF-7-shHMGB2 mice. d The SUVmax was lower in the LoVo-shFOXC1 group than in the control group (*P < 0.05). e Immunohistochemistry showed that HMGB2 expression is negatively correlated with FBP1 expression, but positively correlated with LDHB expression in patients’ samplesBack to article page