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Table 2 Univariate and multivariate Cox’s proportional hazard regression analyses of Pakistani breast cancer cohort for potential predictors of overall survival

From: Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

Characteristics Univariate analysis Multivariate analysis
HR (95% CI) p value HR (95% CI) p value
SHH   3.14 (1.3–7.7) 0.01
Age 0.18 (0.06–0.45) 0.0003 0.2 (0.08–0.56) 0.002
SHH 3.89 (1.6–9.2) 0.002
ER 2.67 (1.2–6.0) 0.02 2.26 (0.97–5.25) 0.05
SHH 3.53 (1.5–8.4) 0.004
PR 1.76 (0.9–3.5) 0.09
SHH 3.58 (1.5–8.6) 0.004
HER-2 1.16 (0.6–2.1) 0.6
SHH 3.93 (1.7–9.3) 0.002
Metastasis 2.96 (1.1–8.3) 0.03 2.62 (1.3–5.3) 0.007
SHH 3.79 (1.6–9.0) 0.002
DHH   2.83 (1.2–6.8) 0.02
Age 0.16 (0.07–0.43) 0.0002 0.17 (0.1–0.5) 0.0003
DHH 2.94 (1.2–6.9) 0.01
ER 2.78 (1.2–6.3) 0.01 2.00 (0.8–4.9) 0.13
DHH 2.42 (1.0–5.8) 0.04
PR 1.97 (1.0–3.85) 0.05 2.04 (0.97–4.3) 0.06
DHH 2.56 (1.1–6.1) 0.03
HER-2 1.16 (0.6–2.1) 0.62
DHH 2.72 (1.2–6.5) 0.02
Metastasis 3.97 (1.9–7.9) 0.0001 2.9(1.4–5.9) 0.003
DHH 3.16 (1.3–7.5) 0.009
GLI1   3.67 (1.7–7.9) 0.0008
Age 0.17 (0.07–0.43) 0.0002 0.18 (0.1–0.5) 0.0004
GLI1 4.67 (2.2–9.8) <0.0001
ER 2.43 (1.1–5.5) 0.03 2.45 (1.1–5.6) 0.03
GLI1 3.98 (1.9–8.4) 0.0003
PR 1.26 (0.6–2.6) 0.52
GLI1 4.15 (1.9–9.1) 0.0004
HER-2 1.01 (0.5–1.9) 0.98
GLI1 4.51 (2.2–9.5) <0.0001
Metastasis 2.54 (1.3–5.1) 0.009 1.85 (1.9–3.8) 0.009
GLI1 4.01 (1.9–8.5) 0.0003
  1. Bold values show significance at p < 0.05, covariates significant in univariate analyses were considered for multivariate analyses