Table 1 Clinical correlation of hedgehog pathway with demographic and pathological variables in Pakistani breast cancer cohort
Variable | Total | MeanāĀ±āSD | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SHH | p-value | DHH | p-value | IHH | p-value | PTCH | p-value | SMO | p-value | GLI-1 | p-value | ||
Tumour | 150 | 4.4Ā Ā±Ā 3.3 | < 0.0001 | 4.7Ā Ā±Ā 3.5 | < 0.0001 | 0.04Ā Ā±Ā 0.2 | < 0.0001 | 3.4Ā Ā±Ā 3.1 | < 0.0001 | 1.4Ā Ā±Ā 2.1 | 0.61 | 3.8Ā Ā±Ā 2.5 | < 0.0001 |
Control | 150 | 1.0Ā Ā±Ā 0.9 | 1.0Ā Ā±Ā 1.4 | 1.0Ā Ā±Ā 1.1 | 1.0Ā Ā±Ā 1.0 | 1.0Ā Ā±Ā 1.3 | 1.0Ā Ā±Ā 0.8 | ||||||
Disease onset age | |||||||||||||
āAgeāā¤ā45Ā years | 76 | 5.6Ā Ā±Ā 3.9 | 0.03 | 5.5Ā Ā±Ā 4.2 | 0.04 | 0.2Ā Ā±Ā 0.8 | 0.65 | 3.2Ā Ā±Ā 3.1 | 0.26 | 1.9Ā Ā±Ā 2.2 | 0.03 | 6.3Ā Ā±Ā 4.5 | 0.03 |
āAgeāā„ā45Ā years | 74 | 4.2Ā Ā±Ā 3.3 | 3.9Ā Ā±Ā 2.9 | 0.04Ā Ā±Ā 0.2 | 3.6Ā Ā±Ā 3.0 | 1.2Ā Ā±Ā 1.8 | 4.2Ā Ā±Ā 2.7 | ||||||
Menopausal status | |||||||||||||
āPre-Menopausal | 80 | 6.8Ā Ā±Ā 4.8 | 0.0065 | 5.6Ā Ā±Ā 3.9 | 0.01 | 0.23Ā Ā±Ā 0.8 | 0.45 | 0.2Ā Ā±Ā 0.8 | < 0.0001 | 2.8Ā Ā±Ā 3.6 | 0.12 | 7.9Ā Ā±Ā 4.3 | < 0.0001 |
āPost-Menopausal | 70 | 4.5Ā Ā±Ā 3.5 | 3.9Ā Ā±Ā 3.0 | 0.05Ā Ā±Ā 0.2 | 3.9Ā Ā±Ā 3.3 | 2.1Ā Ā±Ā 3.1 | 3.9Ā Ā±Ā 2.5 | ||||||
Laterality | |||||||||||||
āRight | 75 | 4.2Ā Ā±Ā 2.8 | 0.01 | 5.8Ā Ā±Ā 4.0 | 0.001 | 0.2Ā Ā±Ā 0.8 | 0.13 | 3.4Ā Ā±Ā 2.9 | 0.97 | 2.5Ā Ā±Ā 2.9 | 0.26 | 4.5Ā Ā±Ā 2.9 | 0.02 |
āLeft | 75 | 6.1Ā Ā±Ā 4.1 | 3.8Ā Ā±Ā 3.0 | 0.1Ā Ā±Ā 0.4 | 3.4Ā Ā±Ā 3.2 | 2.1Ā Ā±Ā 3.1 | 6.4Ā Ā±Ā 4.5 | ||||||
Grade-wise distribution | |||||||||||||
āGrade I | 14 | 3.5Ā Ā±Ā 2.7 | 0.0001 | 3.4Ā Ā±Ā 2.4 | 0.48 | 0.2Ā Ā±Ā 0.9 | 0.2 | 2.9Ā Ā±Ā 2.9 | 0.68 | 2.4Ā Ā±Ā 3.5 | 0.11 | 2.8Ā Ā±Ā 1.9 | 0.01 |
āGrade II | 90 | 5.0Ā Ā±Ā 3.8 | 4.9Ā Ā±Ā 3.7 | 0.2Ā Ā±Ā 0.6 | 3.4Ā Ā±Ā 3.2 | 2.6Ā Ā±Ā 3.2 | 3.2Ā Ā±Ā 1.8 | ||||||
āGrade III | 46 | 9.4Ā Ā±Ā 6.5 | 4.9Ā Ā±Ā 3.6 | 0.09Ā Ā±Ā 0.3 | 3.6Ā Ā±Ā 3.2 | 2.1Ā Ā±Ā 3.6 | 5.6Ā Ā±Ā 4.3 | ||||||
Stage-wise distribution | |||||||||||||
āStage I | 34 | 4.2Ā Ā±Ā 3.3 | < 0.0001 | 6.2Ā Ā±Ā 3.6 | < 0.0001 | 0.1Ā Ā±Ā 0.5 | 0.03 | 3Ā Ā±Ā 2.8 | 0.35 | 2.6Ā Ā±Ā 3.3 | 0.09 | 6.7Ā Ā±Ā 3.9 | 0.005 |
āStage II | 68 | 7.1Ā Ā±Ā 4.1 | 8.3Ā Ā±Ā 3.7 | 0.2Ā Ā±Ā 0.7 | 3.3Ā Ā±Ā 3.2 | 2.3Ā Ā±Ā 2.7 | 7.2Ā Ā±Ā 3.6 | ||||||
āStage III | 43 | 8.7Ā Ā±Ā 3.9 | 8.6Ā Ā±Ā 3.8 | 0.1Ā Ā±Ā 0.2 | 3.6Ā Ā±Ā 2.9 | 1.3Ā Ā±Ā 1.7 | 7.9Ā Ā±Ā 3.8 | ||||||
āStage IV | 5 | 14.6Ā Ā±Ā 2.9 | 17Ā Ā±Ā 2.2 | 0.06Ā Ā±Ā 0.1 | 4.9Ā Ā±Ā 2.8 | 2.3Ā Ā±Ā 1.9 | 14.5Ā Ā±Ā 3 | ||||||
Nodal Involvement | |||||||||||||
āN0 (none) | 48 | 4.3Ā Ā±Ā 3.2 | < 0.0001 | 3.3Ā Ā±Ā 2.8 | 0.01 | 0.2Ā Ā±Ā 0.5 | 0.02 | 2.9Ā Ā±Ā 3 | 0.34 | 2.6Ā Ā±Ā 3.2 | 0.92 | 4.1Ā Ā±Ā 2.7 | 0.003 |
āN1(lymph nodeā<ā4) | 78 | 6.1Ā Ā±Ā 4.1 | 5.8Ā Ā±Ā 4.2 | 0.2Ā Ā±Ā 0.7 | 3.6Ā Ā±Ā 3.2 | 2.3Ā Ā±Ā 3.3 | 5.9Ā Ā±Ā 3.6 | ||||||
āN2(lymph nodeā>ā4) | 24 | 8.2Ā Ā±Ā 3.7 | 6.5Ā Ā±Ā 4.4 | 0.006Ā Ā±Ā 0 | 3.6Ā Ā±Ā 2.8 | 2.7Ā Ā±Ā 3.9 | 6.6Ā Ā±Ā 3.9 | ||||||
Distant Metastasis | |||||||||||||
āM0 | 145 | 4.4Ā Ā±Ā 3.4 | 0.0003 | 4.5Ā Ā±Ā 3.4 | 0.0002 | 0.14Ā Ā±Ā 0.6 | 0.09 | 3.3Ā Ā±Ā 3.0 | 0.12 | 2.4Ā Ā±Ā 3.4 | 0.34 | 3.8Ā Ā±Ā 2.5 | 0.0002 |
āM1 | 5 | 14.6Ā Ā±Ā 2.9 | 17Ā Ā±Ā 2.2 | 0.06Ā Ā±Ā 0.1 | 4.9Ā Ā±Ā 2.8 | 2.3Ā Ā±Ā 1.8 | 14.5Ā Ā±Ā 3 | ||||||
Molecular subtypes | |||||||||||||
āHER-2 | 21 | 2.7Ā Ā±Ā 2.4 | < 0.0001 | 2.2Ā Ā±Ā 1.1 | < 0.0001 | 0.03Ā Ā±Ā 0.1 | 0.73 | 4.3Ā Ā±Ā 4.5 | 0.04 | 2.5Ā Ā±Ā 3 | 0.63 | 3.7Ā Ā±Ā 2.1 | 0.0007 |
āLuminal A | 23 | 5.3Ā Ā±Ā 2.8 | 1.9Ā Ā±Ā 1.6 | 0.06Ā Ā±Ā 0.2 | 2.1Ā Ā±Ā 1.9 | 1.9Ā Ā±Ā 2.7 | 2.7Ā Ā±Ā 1.6 | ||||||
āLuminal B | 79 | 6.7Ā Ā±Ā 2.7 | 4.9Ā Ā±Ā 3.5 | 0.1Ā Ā±Ā 0.4 | 3.7Ā Ā±Ā 3 | 2.6Ā Ā±Ā 3.4 | 5.2Ā Ā±Ā 2.9 | ||||||
āTriple Negative | 27 | 5.9Ā Ā±Ā 3.2 | 2.9Ā Ā±Ā 2.6 | 0.3Ā Ā±Ā 0.8 | 4.1Ā Ā±Ā 3.8 | 1.8Ā Ā±Ā 2.8 | 3.8Ā Ā±Ā 2.5 | ||||||