Fig. 1
From: A functional role of LEFTY during progesterone therapy for endometrial carcinoma
IHC and ISH findings for LEFTY expression in normal and malignant endometrium. a Upper: staining by hematoxylin and eosin (HE) and IHC for LEFTY during the menstrual cycle in normal endometrium. Original magnification, ×200. Lower: IHC score for LEFTY in glandular and stromal components of normal endometrium. b Upper: staining by HE and ISH for LEFTY1 and LEFTY2 mRNAs in normal endometrium. Note the ISH signals in glandular (indicated by arrows) and stroma components (indicated by asterisks). Original magnification, ×400. Lower: ISH scores for LEFTY1 and LEFTY2 mRNAs in glandular and stromal components of normal endometrium. c Upper: staining by HE and IHC for LEFTY in endometrial hyperplasia, and grade (G) 1 and G3 Em Cas. Original magnification, ×200. Lower: IHC score for LEFTY in normal (N), hyperplastic (H), and malignant (G1, G2, G3) endometrium. d Upper: staining by HE and ISH for LEFTY1 and LEFTY2 mRNAs in G1 Em Cas. Note the weak ISH signals for LEFTY1 mRNA in G3 Em Cas (indicated by arrows), in contrast to the strong signals in G1 tumors. Original magnification, ×400. Lower: ISH scores for LEFTY1 (L1) and LEFTY2 (L2) mRNAs in Em Cas. Pro, proliferative stage; Se, early secretory stage; Sl, late secretory stage; Ms., menstrual stage. All data shown are means ± SDs