Fig. 5
From: NFAT1-regulated IL6 signalling contributes to aggressive phenotypes of glioma
Role of IL6R in tumour growth in vivo. a IHC staining for IL6R from intracranial tumours demonstrating IL6R silencing in M1-IL6R-shRNA1 and M1-IL6R-shRNA2 injected mice. Scale bar = 25 μm. Kaplan–Meier survival curves show the survival differences of mice injected with M1-control-shRNA, M1-IL6R-shRNA1 and M1-IL6R-shRNA2 cells, respectively. b IL6R knockdown significantly inhibited intracranial tumour growth. c IL6R silencing significantly inhibited subcutaneous tumour growth. d IHC staining for IL6R from intracranial tumours demonstrating IL6R overexpression in N2-IL6R-OE injected mice. Scale bar = 25 μm. Kaplan–Meier survival curves show the survival differences of mice injected with N2-EV-control and N2-IL6R-OE cells, respectively. e IL6R overexpression promoted intracranial tumour growth. f IL6R overexpression significantly increased subcutaneous tumour growth. *P < 0.05 and **P < 0.01