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Table 1 Correlation of ATIC mRNA expression with clinicopathologic features in HCC

From: Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling

 

ATIC mRNA expression△

p value

Variable

Low (117)

high (117)

(chi-square)

Gender

 Male

83

81

0.8865

 Female

34

36

 

Diagnosis Age

  ≤ 50

23

30

0.3488

  > 50

94

87

 

AFP (ng/mL)

  ≤ 200

97

74

0.0011*

  > 200

20

43

 

Hepatitis status

 Negative

61

44

0.0352*

 Positive

56

73

 

Vascular Invasion

 No

85

69

0.0384*

 Yes

32

48

 

Histologic Grade

 G1

17

9

0.0006*

 G2

64

43

 

 G3-G4

36

65

 

TNM stage

 I

78

56

0.0086*

 II

24

31

 

 III-IV

15

30

 
  1. △, A median split is performed. *, Represents p values with significant difference
  2. TNM, Tumor node metastasis. Data from TCGA database (http://www.cbioportal.org/)
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Cell Communication and Signaling

ISSN: 1478-811X