Fig. 3

Dose-dependent response of apoptosis signaling with varied initial concentrations. Initial concentrations of (a) CD36, (b) Fas, (c) procaspase-3, (d) XIAP, and (e) PARP were varied 10-fold above (right column) and below (left column) the baseline values (center column). The model was used to simulate cPARP level in response to four different TSP1 concentrations: 0.1, 1, 10, and 100 nM. The predicted cPARP level at 24 h was generated using the 12 best sets of parameter values for each condition. The mean cPARP concentration is plotted; error bars show the standard deviation