Fig. 3
From: Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure
Tacrolimus impairs mitochondrial respiration in beta-cells. Analysis of oxygen consumption rate (OCR) in beta-cells incubated for 24 h with vehicle or 25 nM tacrolimus and then treated with glucose, oligomycin, phenylhydrazone (FCCP), antimycin A and rotenone, at the indicated times (a). Data represent mean ± S.E.M. of at least 4 independent experiments. b Quantification of the maximal respiratory capacity: whiskers indicate 1% to 99% spread of the data; *:p < 0.01 vs vehicle