Fig. 2
From: CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion
Structural validation of the relationship between CD44 and CD146. Immunoblot data illustrating the inhibition of CD44 expression in B4 cells using 50 nM of human specific CD44-siRNA. The CD44 inhibition resulted in a marked rescue of CD146 expression. Shown are the cropped blot images representing indicated proteins, and all the gels from three separate experiments have been run under the same experimental conditions. Densitometry was carried out to measure protein expression levels for both CD44 and CD146 (both control and treated sample are shown in the histogram). The values of protein expression levels shown in the histogram are representative of the average calculated from triplicate experiments. The difference is considered statistically significant (student’s two-tailed t-test, P < 0.001)