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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: NF-κB potentiates tumor growth by suppressing a novel target LPTS

Fig. 4

NF-κB directly binds to LPTS promoter. a EMSA was conducted to examine the DNA binding activity of NF-κB. Probe 1 contains the potential NF-κB binding site locating at −888/−881, and probe 2 contains another NF-κB binding site at −1143/−1136 in the human LPTS promoter. Representative images were shown. b ChIP assays were performed to determine the binding activity between NF-κB and the potential elements (−888/−881; −1143/−1136) in the human LPTS promoter in CaSki cells (n = 4, *P < 0.05, **P < 0.01, means ± s.e.ms., Student’s t-test). c Percentage relative to input DNA for p65 ChIP. CaSki cells were treated and harvested as described in (b). (n = 3, *P < 0.05, means ± s.e.ms., Student’s t-test)

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