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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway

Fig. 2

Synthetic lethal interactions to identify molecular targets for cancer therapy: Sensitizing genetically defined tumor cells by targeted inhibition of DNA damage repair pathways. A model for synthetic lethality using PARP inhibitors. In breast/ovarian tumor cells, mutation in BRCA1/2 leaves the cancer cell vulnerable to chemotherapeutic drugs against single strand break repair (SSBR). In contrast, cells with functional BRCA1/2 genes are spared as they can repair the lesions on the DNA using double strand break repair (DSBR) pathway. Compromised base excision repair (BER) pathway combined with homologous recombination (HR) deficiency leads to tumor cell death

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