Fig. 5
From: Crosstalk between glial and glioblastoma cells triggers the “go-or-grow” phenotype of tumor cells
Proposed model for the molecular crosstalk between glial and glioma cells. Glioma cells secrete factors (blue dots) that act in a paracrine fashion to modulate glial cells. These, in turn, alter their secretome profile (red dots) in a way that regulates the malignant phenotype of glioma cells. For example, IBP-2, TIMP-2, FN, MYDGF and SPARCLP1 are among the upregulated proteins in the secretome of primed glial cells, which may mediate the increased viability, and the decreased cell death and migration of glioma cells through the activation of ERK, AKT and JNK signaling pathways