Fig. 8

CLCA1 expression level upregulation inhibits EMT and Wnt/beta-catenin signaling. a Western blotting analysis showed that the increased expression level of CLCA1 increased the E-cadherin expression level but repressed N-cadherin, vimentin, slug, and snail expression levels. CLCA1 expression level downregulation caused the reverse effects. b Beta-catenin nuclear translocation was decreased after CLCA1 expression level was upregulated and increased after CLCA1 was knocked down. c The expression levels of beta-catenin and mesenchymal markers were downregulated in CLCA1-KO cells after treatment with XAV939. Abbreviations: EMT, epithelial-mesenchymal transition