Skip to main content

Table 1 Core components of Hh pathway in Drosophila and vertebrates

From: The emerging roles of phosphatases in Hedgehog pathway

Component Function

Protein Type

Drosophila Protein

Vertebrate Protein

Ligand

Secreted protein

Hedgehog (Hh)

Sonic Hedgehog (Shh),

Desert Hedgehog (Dhh),

Indian Hedgehog (Ihh)

Receptor

12-transmembrane protein

Patched (Ptc)

Patched1 (Ptch1),

Patched2 (Ptch2)

Transcriptional activator and repressor

Zinc finger transcription factor

Cubitus interruptus (Ci)

Glioma-associated oncogene homologue (Gli1–3)

Signal activator

7-transmembrane protein,

G-protein-coupled-receptor (GPCR)

Smoothened (Smo)

Smo

Signal transducer

Kinesin-like protein

Costal2 (Cos2)

Kinesin family member 7 (Kif7)

Ser/Thr Kinase

Fused (Fu)

Fu/STK36

PEST domain protein

Suppressor of Fused (Sufu)

Sufu