TY - JOUR AU - Varjosalo, M. AU - Taipale, J. PY - 2008 DA - 2008// TI - Hedgehog: functions and mechanisms JO - Genes Dev VL - 22 UR - https://doi.org/10.1101/gad.1693608 DO - 10.1101/gad.1693608 ID - Varjosalo2008 ER - TY - JOUR AU - Jiang, J. AU - Hui, C. C. PY - 2008 DA - 2008// TI - Hedgehog signaling in development and cancer JO - Dev Cell VL - 15 UR - https://doi.org/10.1016/j.devcel.2008.11.010 DO - 10.1016/j.devcel.2008.11.010 ID - Jiang2008 ER - TY - JOUR AU - Pak, E. AU - Segal, R. A. PY - 2016 DA - 2016// TI - Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy JO - Dev Cell VL - 38 UR - https://doi.org/10.1016/j.devcel.2016.07.026 DO - 10.1016/j.devcel.2016.07.026 ID - Pak2016 ER - TY - JOUR AU - Singh, V. AU - Ram, M. AU - Kumar, R. AU - Prasad, R. AU - Roy, B. K. AU - Singh, K. K. PY - 2017 DA - 2017// TI - Phosphorylation: Implications in Cancer JO - Protein J. VL - 36 UR - https://doi.org/10.1007/s10930-017-9696-z DO - 10.1007/s10930-017-9696-z ID - Singh2017 ER - TY - JOUR AU - Cohen, P. PY - 2000 DA - 2000// TI - The regulation of protein function by multisite phosphorylation: a 25 year update JO - Trends Biochem Sci VL - 25 UR - https://doi.org/10.1016/S0968-0004(00)01712-6 DO - 10.1016/S0968-0004(00)01712-6 ID - Cohen2000 ER - TY - JOUR AU - Virshup, D. M. AU - Shenolikar, S. PY - 2009 DA - 2009// TI - From promiscuity to precision: protein phosphatases get a makeover JO - Mol Cell VL - 33 UR - https://doi.org/10.1016/j.molcel.2009.02.015 DO - 10.1016/j.molcel.2009.02.015 ID - Virshup2009 ER - TY - JOUR AU - Chen, Y. AU - Jiang, J. PY - 2013 DA - 2013// TI - Decoding the phosphorylation code in hedgehog signal transduction JO - Cell Res VL - 23 UR - https://doi.org/10.1038/cr.2013.10 DO - 10.1038/cr.2013.10 ID - Chen2013 ER - TY - JOUR AU - Aikin, R. A. AU - Ayers, K. L. AU - Therond, P. P. PY - 2008 DA - 2008// TI - The role of kinases in the hedgehog signalling pathway JO - EMBO Rep VL - 9 UR - https://doi.org/10.1038/embor.2008.38 DO - 10.1038/embor.2008.38 ID - Aikin2008 ER - TY - JOUR AU - Ingham, P. W. PY - 2016 DA - 2016// TI - Drosophila segment polarity mutants and the rediscovery of the hedgehog pathway genes JO - Curr Top Dev Biol VL - 116 UR - https://doi.org/10.1016/bs.ctdb.2016.01.007 DO - 10.1016/bs.ctdb.2016.01.007 ID - Ingham2016 ER - TY - JOUR AU - Marigo, V. AU - Davey, R. A. AU - Zuo, Y. AU - Cunningham, J. M. AU - Tabin, C. J. PY - 1996 DA - 1996// TI - Biochemical evidence that patched is the hedgehog receptor JO - Nature VL - 384 UR - https://doi.org/10.1038/384176a0 DO - 10.1038/384176a0 ID - Marigo1996 ER - TY - JOUR AU - Chen, Y. AU - Struhl, G. PY - 1996 DA - 1996// TI - Dual roles for patched in sequestering and transducing hedgehog JO - Cell VL - 87 UR - https://doi.org/10.1016/S0092-8674(00)81374-4 DO - 10.1016/S0092-8674(00)81374-4 ID - Chen1996 ER - TY - JOUR AU - Alcedo, J. AU - Ayzenzon, M. AU - Ohlen, T. AU - Noll, M. AU - Hooper, J. E. PY - 1996 DA - 1996// TI - The drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal JO - Cell VL - 86 UR - https://doi.org/10.1016/S0092-8674(00)80094-X DO - 10.1016/S0092-8674(00)80094-X ID - Alcedo1996 ER - TY - JOUR AU - Heuvel, M. AU - Ingham, P. W. PY - 1996 DA - 1996// TI - smoothened encodes a receptor-like serpentine protein required for hedgehog signaling JO - Nature VL - 382 UR - https://doi.org/10.1038/382547a0 DO - 10.1038/382547a0 ID - Heuvel1996 ER - TY - JOUR AU - Alexandre, C. AU - Jacinto, A. AU - Ingham, P. W. PY - 1996 DA - 1996// TI - Transcriptional activation of hedgehog target genes in drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins JO - Genes Dev VL - 10 UR - https://doi.org/10.1101/gad.10.16.2003 DO - 10.1101/gad.10.16.2003 ID - Alexandre1996 ER - TY - JOUR AU - Monnier, V. AU - Dussillol, F. AU - Alves, G. AU - Lamour-Isnard, C. AU - Plessis, A. PY - 1998 DA - 1998// TI - Suppressor of fused links fused and Cubitus interruptus on the hedgehog signaling pathway JO - Curr Biol VL - 8 UR - https://doi.org/10.1016/S0960-9822(98)70227-1 DO - 10.1016/S0960-9822(98)70227-1 ID - Monnier1998 ER - TY - JOUR AU - Sisson, J. C. AU - Ho, K. S. AU - Suyama, K. AU - Scott, M. P. PY - 1997 DA - 1997// TI - Costal2, a novel kinesin-related protein in the hedgehog signaling pathway JO - Cell VL - 90 UR - https://doi.org/10.1016/S0092-8674(00)80332-3 DO - 10.1016/S0092-8674(00)80332-3 ID - Sisson1997 ER - TY - JOUR AU - Therond, P. AU - Limbourg Bouchon, B. AU - Gallet, A. AU - Dussillol, F. AU - Pietri, T. AU - Heuvel, M. AU - Tricoire, H. PY - 1999 DA - 1999// TI - Differential requirements of the fused kinase for hedgehog signaling in the drosophila embryo JO - Development VL - 126 ID - Therond1999 ER - TY - JOUR AU - Wilson, C. W. AU - Chuang, P. T. PY - 2010 DA - 2010// TI - Mechanism and evolution of cytosolic hedgehog signal transduction JO - Development VL - 137 UR - https://doi.org/10.1242/dev.045021 DO - 10.1242/dev.045021 ID - Wilson2010 ER - TY - JOUR AU - Huangfu, D. AU - Anderson, K. V. PY - 2006 DA - 2006// TI - Signaling from Smo to ci/Gli: conservation and divergence of hedgehog pathways from drosophila to vertebrates JO - Development VL - 133 UR - https://doi.org/10.1242/dev.02169 DO - 10.1242/dev.02169 ID - Huangfu2006 ER - TY - JOUR AU - Hui, C. C. AU - Angers, S. PY - 2011 DA - 2011// TI - Gli proteins in development and disease JO - Annu Rev Cell Dev Biol VL - 27 UR - https://doi.org/10.1146/annurev-cellbio-092910-154048 DO - 10.1146/annurev-cellbio-092910-154048 ID - Hui2011 ER - TY - JOUR AU - Kuzhandaivel, A. AU - Schultz, S. W. AU - Alkhori, L. AU - Alenius, M. PY - 2014 DA - 2014// TI - Cilia-mediated hedgehog signaling in drosophila JO - Cell Rep VL - 7 UR - https://doi.org/10.1016/j.celrep.2014.03.052 DO - 10.1016/j.celrep.2014.03.052 ID - Kuzhandaivel2014 ER - TY - JOUR AU - Zhang, C. AU - Williams, E. AU - Guo, Y. AU - Lum, L. AU - Beachy, P. PY - 2004 DA - 2004// TI - Extensive phosphorylation of smoothened in hedgehog pathway activation JO - Proc Natl Acad Sci U S A VL - 101 UR - https://doi.org/10.1073/pnas.0408093101 DO - 10.1073/pnas.0408093101 ID - Zhang2004 ER - TY - JOUR AU - Jia, J. AU - Tong, C. AU - Wang, B. AU - Luo, L. AU - Jiang, J. PY - 2004 DA - 2004// TI - Hedgehog signaling activity of smoothened requires phosphorylation by protein kinase a and casein kinase I JO - Nature VL - 432 UR - https://doi.org/10.1038/nature03179 DO - 10.1038/nature03179 ID - Jia2004 ER - TY - JOUR AU - Apionishev, S. AU - Katanayeva, N. M. AU - Marks, S. A. AU - Kalderon, D. AU - Tomlinson, A. PY - 2005 DA - 2005// TI - Drosophila smoothened phosphorylation sites essential for hedgehog signal transduction JO - Nat Cell Biol VL - 7 UR - https://doi.org/10.1038/ncb1210 DO - 10.1038/ncb1210 ID - Apionishev2005 ER - TY - JOUR AU - Li, S. AU - Chen, Y. AU - Shi, Q. AU - Yue, T. AU - Wang, B. AU - Jiang, J. PY - 2012 DA - 2012// TI - Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in drosophila JO - PLoS Biol VL - 10 UR - https://doi.org/10.1371/journal.pbio.1001239 DO - 10.1371/journal.pbio.1001239 ID - Li2012 ER - TY - JOUR AU - Xia, R. AU - Jia, H. AU - Fan, J. AU - Liu, Y. AU - Jia, J. PY - 2012 DA - 2012// TI - USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization JO - PLoS Biol VL - 10 UR - https://doi.org/10.1371/journal.pbio.1001238 DO - 10.1371/journal.pbio.1001238 ID - Xia2012 ER - TY - JOUR AU - Zhao, Y. AU - Tong, C. AU - Jiang, J. PY - 2007 DA - 2007// TI - Hedgehog regulates smoothened activity by inducing a conformational switch JO - Nature VL - 450 UR - https://doi.org/10.1038/nature06225 DO - 10.1038/nature06225 ID - Zhao2007 ER - TY - JOUR AU - Maier, D. AU - Cheng, S. AU - Faubert, D. AU - Hipfner, D. R. PY - 2014 DA - 2014// TI - A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls drosophila smoothened activity JO - PLoS Genet VL - 10 UR - https://doi.org/10.1371/journal.pgen.1004399 DO - 10.1371/journal.pgen.1004399 ID - Maier2014 ER - TY - JOUR AU - Chen, Y. AU - Li, S. AU - Tong, C. AU - Zhao, Y. AU - Wang, B. AU - Liu, Y. AU - Jia, J. AU - Jiang, J. PY - 2010 DA - 2010// TI - G protein-coupled receptor kinase 2 promotes high-level hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in drosophila JO - Genes Dev VL - 24 UR - https://doi.org/10.1101/gad.1948710 DO - 10.1101/gad.1948710 ID - Chen2010 ER - TY - JOUR AU - Molnar, C. AU - Holguin, H. AU - Mayor, F. AU - Ruiz-Gomez, A. AU - Celis, J. F. PY - 2007 DA - 2007// TI - The G protein-coupled receptor regulatory kinase GPRK2 participates in hedgehog signaling in drosophila JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0702374104 DO - 10.1073/pnas.0702374104 ID - Molnar2007 ER - TY - JOUR AU - Cheng, S. AU - Maier, D. AU - Neubueser, D. AU - Hipfner, D. R. PY - 2010 DA - 2010// TI - Regulation of smoothened by drosophila G-protein-coupled receptor kinases JO - Dev Biol VL - 337 UR - https://doi.org/10.1016/j.ydbio.2009.10.014 DO - 10.1016/j.ydbio.2009.10.014 ID - Cheng2010 ER - TY - JOUR AU - Li, S. AU - Li, S. AU - Han, Y. AU - Tong, C. AU - Wang, B. AU - Chen, Y. AU - Jiang, J. PY - 2016 DA - 2016// TI - Regulation of smoothened phosphorylation and high-level hedgehog signaling activity by a plasma membrane associated kinase JO - PLoS Biol VL - 14 UR - https://doi.org/10.1371/journal.pbio.1002481 DO - 10.1371/journal.pbio.1002481 ID - Li2016 ER - TY - JOUR AU - Chen, Y. AU - Sasai, N. AU - Ma, G. AU - Yue, T. AU - Jia, J. AU - Briscoe, J. AU - Jiang, J. PY - 2011 DA - 2011// TI - Sonic hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened JO - PLoS Biol VL - 9 UR - https://doi.org/10.1371/journal.pbio.1001083 DO - 10.1371/journal.pbio.1001083 ID - Chen2011 ER - TY - JOUR AU - Philipp, M. AU - Fralish, G. B. AU - Meloni, A. R. AU - Chen, W. AU - MacInnes, A. W. AU - Barak, L. S. AU - Caron, M. G. PY - 2008 DA - 2008// TI - Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase JO - Mol Biol Cell VL - 19 UR - https://doi.org/10.1091/mbc.E08-05-0448 DO - 10.1091/mbc.E08-05-0448 ID - Philipp2008 ER - TY - JOUR AU - Meloni, A. R. AU - Fralish, G. B. AU - Kelly, P. AU - Salahpour, A. AU - Chen, J. K. AU - Wechsler-Reya, R. J. AU - Lefkowitz, R. J. AU - Caron, M. G. PY - 2006 DA - 2006// TI - Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 JO - Mol Cell Biol VL - 26 UR - https://doi.org/10.1128/MCB.00546-06 DO - 10.1128/MCB.00546-06 ID - Meloni2006 ER - TY - JOUR AU - Chen, W. AU - Ren, X. -. R. AU - Nelson, C. D. AU - Barak, L. S. AU - Chen, J. K. AU - Beachy, P. AU - Sauvage, F. AU - Lefkowitz, R. J. PY - 2004 DA - 2004// TI - Activity-dependent internalization of smoothened mediated by b-Arrestin 2 and GRK2 JO - Science VL - 306 UR - https://doi.org/10.1126/science.1104135 DO - 10.1126/science.1104135 ID - Chen2004 ER - TY - JOUR AU - Price, M. A. AU - Kalderon, D. PY - 1999 DA - 1999// TI - Proteolysis of cubitus interruptus in drosophila requires phosphorylation by protein kinase a JO - Development VL - 126 ID - Price1999 ER - TY - JOUR AU - Price, M. A. AU - Kalderon, D. PY - 2002 DA - 2002// TI - Proteolysis of the hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1 JO - Cell VL - 108 UR - https://doi.org/10.1016/S0092-8674(02)00664-5 DO - 10.1016/S0092-8674(02)00664-5 ID - Price2002 ER - TY - JOUR AU - Jia, J. AU - Amanai, K. AU - Wang, G. AU - Tang, J. AU - Wang, B. AU - Jiang, J. PY - 2002 DA - 2002// TI - Shaggy/GSK3 antagonizes hedgehog signalling by regulating Cubitus interruptus JO - Nature VL - 416 UR - https://doi.org/10.1038/nature733 DO - 10.1038/nature733 ID - Jia2002 ER - TY - JOUR AU - Jia, J. AU - Zhang, L. AU - Zhang, Q. AU - Tong, C. AU - Wang, B. AU - Hou, F. AU - Amanai, K. AU - Jiang, J. PY - 2005 DA - 2005// TI - Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing JO - Dev Cell VL - 9 UR - https://doi.org/10.1016/j.devcel.2005.10.006 DO - 10.1016/j.devcel.2005.10.006 ID - Jia2005 ER - TY - JOUR AU - Smelkinson, M. G. AU - Kalderon, D. PY - 2006 DA - 2006// TI - Processing of the drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb JO - Curr Biol VL - 16 UR - https://doi.org/10.1016/j.cub.2005.12.012 DO - 10.1016/j.cub.2005.12.012 ID - Smelkinson2006 ER - TY - JOUR AU - Smelkinson, M. G. AU - Zhou, Q. AU - Kalderon, D. PY - 2007 DA - 2007// TI - Regulation of ci-SCFSlimb binding, ci proteolysis, and hedgehog pathway activity by ci phosphorylation JO - Dev Cell VL - 13 UR - https://doi.org/10.1016/j.devcel.2007.09.006 DO - 10.1016/j.devcel.2007.09.006 ID - Smelkinson2007 ER - TY - JOUR AU - Wang, B. AU - Li, Y. PY - 2006 DA - 2006// TI - Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0509927103 DO - 10.1073/pnas.0509927103 ID - Wang2006 ER - TY - JOUR AU - Tempe, D. AU - Casas, M. AU - Karaz, S. AU - Blanchet-Tournier, M. F. AU - Concordet, J. P. PY - 2006 DA - 2006// TI - Multisite protein kinase a and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP JO - Mol Cell Biol VL - 26 UR - https://doi.org/10.1128/MCB.02183-05 DO - 10.1128/MCB.02183-05 ID - Tempe2006 ER - TY - JOUR AU - Pan, Y. AU - Bai, C. B. AU - Joyner, A. L. AU - Wang, B. PY - 2006 DA - 2006// TI - Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation JO - Mol Cell Biol VL - 26 UR - https://doi.org/10.1128/MCB.26.9.3365-3377.2006 DO - 10.1128/MCB.26.9.3365-3377.2006 ID - Pan2006 ER - TY - JOUR AU - Kent, D. AU - Bush, E. W. AU - Hooper, J. E. PY - 2006 DA - 2006// TI - Roadkill attenuates hedgehog responses through degradation of Cubitus interruptus JO - Development VL - 133 UR - https://doi.org/10.1242/dev.02370 DO - 10.1242/dev.02370 ID - Kent2006 ER - TY - JOUR AU - Zhang, Q. AU - Zhang, L. AU - Wang, B. AU - Ou, C. Y. AU - Chien, C. T. AU - Jiang, J. PY - 2006 DA - 2006// TI - A hedgehog-induced BTB protein modulates hedgehog signaling by degrading ci/Gli transcription factor JO - Dev Cell VL - 10 UR - https://doi.org/10.1016/j.devcel.2006.05.004 DO - 10.1016/j.devcel.2006.05.004 ID - Zhang2006 ER - TY - JOUR AU - Zhang, Q. AU - Shi, Q. AU - Chen, Y. AU - Yue, T. AU - Li, S. AU - Wang, B. AU - Jiang, J. PY - 2009 DA - 2009// TI - Multiple Ser/Thr-rich degrons mediate the degradation of ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase JO - Proc Natl Acad Sci U S A VL - 106 UR - https://doi.org/10.1073/pnas.0912008106 DO - 10.1073/pnas.0912008106 ID - Zhang2009 ER - TY - JOUR AU - Shi, Q. AU - Li, S. AU - Li, S. AU - Jiang, A. AU - Chen, Y. AU - Jiang, J. PY - 2014 DA - 2014// TI - Hedgehog-induced phosphorylation by CK1 sustains the activity of ci/Gli activator JO - Proc Natl Acad Sci U S A VL - 111 UR - https://doi.org/10.1073/pnas.1416652111 DO - 10.1073/pnas.1416652111 ID - Shi2014 ER - TY - JOUR AU - Jia, H. AU - Liu, Y. AU - Xia, R. AU - Tong, C. AU - Yue, T. AU - Jiang, J. AU - Jia, J. PY - 2010 DA - 2010// TI - Casein kinase 2 promotes hedgehog signaling by regulating both smoothened and Cubitus interruptus JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.174565 DO - 10.1074/jbc.M110.174565 ID - Jia2010 ER - TY - JOUR AU - Varjosalo, M. AU - Bjorklund, M. AU - Cheng, F. AU - Syvanen, H. AU - Kivioja, T. AU - Kilpinen, S. AU - Sun, Z. AU - Kallioniemi, O. AU - Stunnenberg, H. G. AU - He, W. W. PY - 2008 DA - 2008// TI - Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling JO - Cell VL - 133 UR - https://doi.org/10.1016/j.cell.2008.02.047 DO - 10.1016/j.cell.2008.02.047 ID - Varjosalo2008 ER - TY - JOUR AU - Mao, J. AU - Maye, P. AU - Kogerman, P. AU - Tejedor, F. J. AU - Toftgard, R. AU - Xie, W. AU - Wu, G. AU - Wu, D. PY - 2002 DA - 2002// TI - Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1 JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M206743200 DO - 10.1074/jbc.M206743200 ID - Mao2002 ER - TY - JOUR AU - Schneider, P. AU - Bayo-Fina, J. M. AU - Singh, R. AU - Kumar Dhanyamraju, P. AU - Holz, P. AU - Baier, A. AU - Fendrich, V. AU - Ramaswamy, A. AU - Baumeister, S. AU - Martinez, E. D. AU - Lauth, M. PY - 2015 DA - 2015// TI - Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1 JO - Nat Commun VL - 6 UR - https://doi.org/10.1038/ncomms9023 DO - 10.1038/ncomms9023 ID - Schneider2015 ER - TY - JOUR AU - Lum, L. AU - Zhang, C. AU - Oh, S. AU - Mann, R. AU - Kessler, D. AU - Taipale, J. AU - Weis-Garcia, F. AU - Gong, R. AU - Wang, B. AU - Beachy, P. PY - 2003 DA - 2003// TI - Hedgehog signal transduction via smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 JO - Mol Cell VL - 12 UR - https://doi.org/10.1016/S1097-2765(03)00426-X DO - 10.1016/S1097-2765(03)00426-X ID - Lum2003 ER - TY - JOUR AU - Shi, Q. AU - Li, S. AU - Jia, J. AU - Jiang, J. PY - 2011 DA - 2011// TI - The hedgehog-induced smoothened conformational switch assembles a signaling complex that activates fused by promoting its dimerization and phosphorylation JO - Development VL - 138 UR - https://doi.org/10.1242/dev.067959 DO - 10.1242/dev.067959 ID - Shi2011 ER - TY - JOUR AU - Jia, J. AU - Tong, C. AU - Jiang, J. PY - 2003 DA - 2003// TI - Smoothened transduces hedgehog signal by physically interacting with Costal2/fused complex through its C-terminal tail JO - Genes Dev VL - 17 UR - https://doi.org/10.1101/gad.1136603 DO - 10.1101/gad.1136603 ID - Jia2003 ER - TY - JOUR AU - Zhou, Q. AU - Kalderon, D. PY - 2011 DA - 2011// TI - Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses JO - Dev Cell VL - 20 UR - https://doi.org/10.1016/j.devcel.2011.04.020 DO - 10.1016/j.devcel.2011.04.020 ID - Zhou2011 ER - TY - JOUR AU - Hooper, J. E. AU - Scott, M. P. PY - 2005 DA - 2005// TI - Communicating with hedgehogs JO - Nat Rev Mol Cell Biol VL - 6 UR - https://doi.org/10.1038/nrm1622 DO - 10.1038/nrm1622 ID - Hooper2005 ER - TY - JOUR AU - Ingham, P. W. AU - McMahon, A. P. PY - 2001 DA - 2001// TI - Hedgehog signaling in animal development: paradigms and principles JO - Genes Dev VL - 15 UR - https://doi.org/10.1101/gad.938601 DO - 10.1101/gad.938601 ID - Ingham2001 ER - TY - JOUR AU - Raisin, S. AU - Ruel, L. AU - Ranieri, N. AU - Staccini-Lavenant, L. AU - Therond, P. P. PY - 2010 DA - 2010// TI - Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling JO - Dev Biol VL - 344 UR - https://doi.org/10.1016/j.ydbio.2010.04.021 DO - 10.1016/j.ydbio.2010.04.021 ID - Raisin2010 ER - TY - JOUR AU - Ruel, L. AU - Gallet, A. AU - Raisin, S. AU - Truchi, A. AU - Staccini-Lavenant, L. AU - Cervantes, A. AU - Therond, P. P. PY - 2007 DA - 2007// TI - Phosphorylation of the atypical kinesin Costal2 by the kinase fused induces the partial disassembly of the smoothened-fused-Costal2-Cubitus interruptus complex in hedgehog signalling JO - Development VL - 134 UR - https://doi.org/10.1242/dev.011577 DO - 10.1242/dev.011577 ID - Ruel2007 ER - TY - JOUR AU - Therond, P. AU - Knight, J. AU - Kornberg, T. AU - Bishop, J. PY - 1996 DA - 1996// TI - Phosphorylation of the fused protein kinase in response to signaling from hedgehog JO - Proc Natl Acad Sci U S A VL - 93 UR - https://doi.org/10.1073/pnas.93.9.4224 DO - 10.1073/pnas.93.9.4224 ID - Therond1996 ER - TY - JOUR AU - Zhang, Y. AU - Mao, F. AU - Lu, Y. AU - Wu, W. AU - Zhang, L. AU - Zhao, Y. PY - 2011 DA - 2011// TI - Transduction of the hedgehog signal through the dimerization of fused and the nuclear translocation of Cubitus interruptus JO - Cell Res VL - 21 UR - https://doi.org/10.1038/cr.2011.136 DO - 10.1038/cr.2011.136 ID - Zhang2011 ER - TY - JOUR AU - Chen, M. H. AU - Gao, N. AU - Kawakami, T. AU - Chuang, P. T. PY - 2005 DA - 2005// TI - Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development JO - Mol Cell Biol VL - 25 UR - https://doi.org/10.1128/MCB.25.16.7042-7053.2005 DO - 10.1128/MCB.25.16.7042-7053.2005 ID - Chen2005 ER - TY - JOUR AU - Merchant, M. AU - Evangelista, M. AU - Luoh, S. M. AU - Frantz, G. D. AU - Chalasani, S. AU - Carano, R. A. AU - Hoy, M. AU - Ramirez, J. AU - Ogasawara, A. K. AU - McFarland, L. M. PY - 2005 DA - 2005// TI - Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus JO - Mol Cell Biol VL - 25 UR - https://doi.org/10.1128/MCB.25.16.7054-7068.2005 DO - 10.1128/MCB.25.16.7054-7068.2005 ID - Merchant2005 ER - TY - JOUR AU - Maloverjan, A. AU - Piirsoo, M. AU - Michelson, P. AU - Kogerman, P. AU - Osterlund, T. PY - 2010 DA - 2010// TI - Identification of a novel serine/threonine kinase ULK3 as a positive regulator of hedgehog pathway JO - Exp Cell Res VL - 316 UR - https://doi.org/10.1016/j.yexcr.2009.10.018 DO - 10.1016/j.yexcr.2009.10.018 ID - Maloverjan2010 ER - TY - JOUR AU - Maloverjan, A. AU - Piirsoo, M. AU - Kasak, L. AU - Peil, L. AU - Osterlund, T. AU - Kogerman, P. PY - 2010 DA - 2010// TI - Dual function of UNC-51-like kinase 3 (Ulk3) in the sonic hedgehog signaling pathway JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.133991 DO - 10.1074/jbc.M110.133991 ID - Maloverjan2010 ER - TY - JOUR AU - Endoh-Yamagami, S. AU - Evangelista, M. AU - Wilson, D. AU - Wen, X. AU - Theunissen, J. W. AU - Phamluong, K. AU - Davis, M. AU - Scales, S. J. AU - Solloway, M. J. AU - Sauvage, F. J. AU - Peterson, A. S. PY - 2009 DA - 2009// TI - The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development JO - Curr Biol VL - 19 UR - https://doi.org/10.1016/j.cub.2009.06.046 DO - 10.1016/j.cub.2009.06.046 ID - Endoh-Yamagami2009 ER - TY - JOUR AU - Chen, Y. AU - Yue, S. AU - Xie, L. AU - Pu, X. H. AU - Jin, T. AU - Cheng, S. Y. PY - 2011 DA - 2011// TI - Dual phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium JO - J Biol Chem VL - 286 UR - https://doi.org/10.1074/jbc.M110.217604 DO - 10.1074/jbc.M110.217604 ID - Chen2011 ER - TY - JOUR AU - Moorhead, G. B. AU - Wever, V. AU - Templeton, G. AU - Kerk, D. PY - 2009 DA - 2009// TI - Evolution of protein phosphatases in plants and animals JO - Biochem J VL - 417 UR - https://doi.org/10.1042/BJ20081986 DO - 10.1042/BJ20081986 ID - Moorhead2009 ER - TY - JOUR AU - Moorhead, G. B. AU - Trinkle-Mulcahy, L. AU - Ulke-Lemee, A. PY - 2007 DA - 2007// TI - Emerging roles of nuclear protein phosphatases JO - Nat Rev Mol Cell Biol VL - 8 UR - https://doi.org/10.1038/nrm2126 DO - 10.1038/nrm2126 ID - Moorhead2007 ER - TY - STD TI - Su Y, Ospina JK, Zhang J, Michelson AP, Schoen AM, Zhu AJ. Sequential phosphorylation of smoothened transduces graded Hedgehog signaling. Science Signaling. 2011;4:ra43. ID - ref72 ER - TY - JOUR AU - Swarup, S. AU - Pradhan-Sundd, T. AU - Verheyen, E. M. PY - 2015 DA - 2015// TI - Genome-wide identification of phospho-regulators of Wnt signaling in drosophila JO - Development VL - 142 UR - https://doi.org/10.1242/dev.116715 DO - 10.1242/dev.116715 ID - Swarup2015 ER - TY - JOUR AU - Dombradi, V. AU - Axton, J. M. AU - Brewis, N. D. AU - Da cruz e Silva, E. F. AU - Alphey, L. AU - Cohen, P. T. PY - 1990 DA - 1990// TI - drosophila contains three genes that encode distinct isoforms of protein phosphatase 1 JO - FEBS J VL - 194 ID - Dombradi1990 ER - TY - JOUR AU - Dombradi, V. AU - Mann, D. J. AU - Saunders, R. D. AU - Cohen, P. T. PY - 1993 DA - 1993// TI - Cloning of the fourth functional gene for protein phosphatase 1 in Drosophila Melanogaster from its chromosomal location JO - FEBS J VL - 212 ID - Dombradi1993 ER - TY - JOUR AU - Vereshchagina, N. AU - Bennett, D. AU - Szoor, B. AU - Kirchner, J. AU - Gross, S. AU - Vissi, E. AU - White-Cooper, H. AU - Alphey, L. PY - 2004 DA - 2004// TI - The essential role of PP1b in drosophila is to regulate nonmuscle myosin JO - Mol Biol Cell VL - 15 UR - https://doi.org/10.1091/mbc.E04-02-0139 DO - 10.1091/mbc.E04-02-0139 ID - Vereshchagina2004 ER - TY - JOUR AU - Kirchner, J. AU - Gross, S. AU - Bennett, D. AU - Alphey, L. PY - 2007 DA - 2007// TI - Essential, overlapping and redundant roles of the drosophila protein phosphatase 1 alpha and 1 beta genes JO - Genetics VL - 176 UR - https://doi.org/10.1534/genetics.106.069914 DO - 10.1534/genetics.106.069914 ID - Kirchner2007 ER - TY - JOUR AU - Westermarck, J. AU - Hahn, W. C. PY - 2008 DA - 2008// TI - Multiple pathways regulated by the tumor suppressor PP2A in transformation JO - Trends Mol Med VL - 14 UR - https://doi.org/10.1016/j.molmed.2008.02.001 DO - 10.1016/j.molmed.2008.02.001 ID - Westermarck2008 ER - TY - JOUR AU - Mumby, M. PY - 2007 DA - 2007// TI - PP2A: unveiling a reluctant tumor suppressor JO - Cell VL - 130 UR - https://doi.org/10.1016/j.cell.2007.06.034 DO - 10.1016/j.cell.2007.06.034 ID - Mumby2007 ER - TY - JOUR AU - Krishnan, V. AU - Pereira, F. A. AU - Qiu, Y. AU - Chen, C. H. AU - Beachy, P. A. AU - Tsai, S. Y. AU - Tsai, M. J. PY - 1997 DA - 1997// TI - Mediation of sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase JO - Science VL - 278 UR - https://doi.org/10.1126/science.278.5345.1947 DO - 10.1126/science.278.5345.1947 ID - Krishnan1997 ER - TY - JOUR AU - Nybakken, K. AU - Vokes, S. A. AU - Lin, T. Y. AU - McMahon, A. P. AU - Perrimon, N. PY - 2005 DA - 2005// TI - A genome-wide RNA interference screen in Drosophila Melanogaster cells for new components of the Hh signaling pathway JO - Nat Genet VL - 37 UR - https://doi.org/10.1038/ng1682 DO - 10.1038/ng1682 ID - Nybakken2005 ER - TY - JOUR AU - Casso, D. J. AU - Liu, S. AU - Iwaki, D. D. AU - Ogden, S. K. AU - Kornberg, T. B. PY - 2008 DA - 2008// TI - A screen for modifiers of hedgehog signaling in Drosophila Melanogaster identifies swm and mts JO - Genetics VL - 178 UR - https://doi.org/10.1534/genetics.107.081638 DO - 10.1534/genetics.107.081638 ID - Casso2008 ER - TY - JOUR AU - Jia, H. AU - Liu, Y. AU - Yan, W. AU - Jia, J. PY - 2009 DA - 2009// TI - PP4 and PP2A regulate hedgehog signaling by controlling Smo and ci phosphorylation JO - Development VL - 136 UR - https://doi.org/10.1242/dev.030015 DO - 10.1242/dev.030015 ID - Jia2009 ER - TY - STD TI - Liu YC, Couzens AL, Deshwar AR, LD BM-C, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC, Angers S. The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Sci Signal. 2014;7:ra117. ID - ref84 ER - TY - JOUR AU - Krauss, S. AU - So, J. AU - Hambrock, M. AU - Kohler, A. AU - Kunath, M. AU - Scharff, C. AU - Wessling, M. AU - Grzeschik, K. H. AU - Schneider, R. AU - Schweiger, S. PY - 2009 DA - 2009// TI - Point mutations in GLI3 lead to misregulation of its subcellular localization JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0007471 DO - 10.1371/journal.pone.0007471 ID - Krauss2009 ER - TY - JOUR AU - Krauss, S. AU - Foerster, J. AU - Schneider, R. AU - Schweiger, S. PY - 2008 DA - 2008// TI - Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3 JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-6174 DO - 10.1158/0008-5472.CAN-07-6174 ID - Krauss2008 ER - TY - JOUR AU - Jin, Z. AU - Mei, W. AU - Strack, S. AU - Jia, J. AU - Yang, J. PY - 2011 DA - 2011// TI - The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1 JO - J Biol Chem VL - 286 UR - https://doi.org/10.1074/jbc.M111.274761 DO - 10.1074/jbc.M111.274761 ID - Jin2011 ER - TY - JOUR AU - Arnold, C. AU - Lamont, R. AU - Walker, J. AU - Spice, P. AU - Chan, C. AU - Ho, C. AU - Childs, S. PY - 2015 DA - 2015// TI - Comparative analysis of genes regulated by Dzip1/iguana and hedgehog in zebrafish JO - Dev Dyn VL - 244 UR - https://doi.org/10.1002/dvdy.24237 DO - 10.1002/dvdy.24237 ID - Arnold2015 ER - TY - JOUR AU - Manning, G. AU - Plowman, G. D. AU - Hunter, T. AU - Sudarsanam, S. PY - 2002 DA - 2002// TI - Evolution of protein kinase signaling from yeast to man JO - Trends Biochem Sci VL - 27 UR - https://doi.org/10.1016/S0968-0004(02)02179-5 DO - 10.1016/S0968-0004(02)02179-5 ID - Manning2002 ER - TY - JOUR AU - Seshacharyulu, P. AU - Pandey, P. AU - Datta, K. AU - Batra, S. K. PY - 2013 DA - 2013// TI - Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer JO - Cancer Lett VL - 335 UR - https://doi.org/10.1016/j.canlet.2013.02.036 DO - 10.1016/j.canlet.2013.02.036 ID - Seshacharyulu2013 ER - TY - JOUR AU - Sommer, L. M. AU - Cho, H. AU - Choudhary, M. AU - Seeling, J. M. PY - 2015 DA - 2015// TI - Evolutionary analysis of the B56 gene family of PP2A regulatory subunits JO - Int J Mol Sci VL - 16 UR - https://doi.org/10.3390/ijms160510134 DO - 10.3390/ijms160510134 ID - Sommer2015 ER - TY - JOUR AU - Xu, Y. AU - Xing, Y. AU - Chen, Y. AU - Chao, Y. AU - Lin, Z. AU - Fan, E. AU - Yu, J. W. AU - Strack, S. AU - Jeffrey, P. D. AU - Shi, Y. PY - 2006 DA - 2006// TI - Structure of the protein phosphatase 2A holoenzyme JO - Cell VL - 127 UR - https://doi.org/10.1016/j.cell.2006.11.033 DO - 10.1016/j.cell.2006.11.033 ID - Xu2006 ER - TY - JOUR AU - Yang, J. AU - Phiel, C. PY - 2010 DA - 2010// TI - Functions of B56-containing PP2As in major developmental and cancer signaling pathways JO - Life Sci VL - 87 UR - https://doi.org/10.1016/j.lfs.2010.10.003 DO - 10.1016/j.lfs.2010.10.003 ID - Yang2010 ER - TY - JOUR AU - Rorick, A. M. AU - Mei, W. AU - Liette, N. L. AU - Phiel, C. AU - El-Hodiri, H. M. AU - Yang, J. PY - 2007 DA - 2007// TI - PP2A:B56epsilon is required for eye induction and eye field separation JO - Dev Biol VL - 302 UR - https://doi.org/10.1016/j.ydbio.2006.10.011 DO - 10.1016/j.ydbio.2006.10.011 ID - Rorick2007 ER - TY - JOUR AU - Bajpai, R. AU - Makhijani, K. AU - Rao, P. R. AU - Shashidhara, L. S. PY - 2004 DA - 2004// TI - Drosophila twins regulates armadillo levels in response to Wg/Wnt signal JO - Development VL - 131 UR - https://doi.org/10.1242/dev.00980 DO - 10.1242/dev.00980 ID - Bajpai2004 ER - TY - JOUR AU - Chen, J. AU - Peterson, R. T. AU - Schreiber, S. L. PY - 1998 DA - 1998// TI - Alpha 4 associates with protein phosphatases 2A, 4, and 6 JO - Biochem Biophys Res Commun VL - 247 UR - https://doi.org/10.1006/bbrc.1998.8792 DO - 10.1006/bbrc.1998.8792 ID - Chen1998 ER - TY - JOUR AU - Kloeker, S. AU - Reed, R. AU - McConnell, J. L. AU - Chang, D. AU - Tran, K. AU - Westphal, R. S. AU - Law, B. K. AU - Colbran, R. J. AU - Kamoun, M. AU - Campbell, K. S. AU - Wadzinski, B. E. PY - 2003 DA - 2003// TI - Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2AC, PP4C, and PP6C) and analysis of the interaction of PP2AC with alpha4 protein JO - Protein Expr Purif VL - 31 UR - https://doi.org/10.1016/S1046-5928(03)00141-4 DO - 10.1016/S1046-5928(03)00141-4 ID - Kloeker2003 ER - TY - JOUR AU - Lillo, C. AU - Kataya, A. R. AU - Heidari, B. AU - Creighton, M. T. AU - Nemie-Feyissa, D. AU - Ginbot, Z. AU - Jonassen, E. M. PY - 2014 DA - 2014// TI - Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in development and responses to environmental cues JO - Plant Cell Environ VL - 37 UR - https://doi.org/10.1111/pce.12364 DO - 10.1111/pce.12364 ID - Lillo2014 ER - TY - JOUR AU - Kong, M. AU - Ditsworth, D. AU - Lindsten, T. AU - Thompson, C. B. PY - 2009 DA - 2009// TI - Alpha4 is an essential regulator of PP2A phosphatase activity JO - Mol Cell VL - 36 UR - https://doi.org/10.1016/j.molcel.2009.09.025 DO - 10.1016/j.molcel.2009.09.025 ID - Kong2009 ER - TY - JOUR AU - Wang, N. AU - Leung, H. T. AU - Mazalouskas, M. D. AU - Watkins, G. R. AU - Gomez, R. J. AU - Wadzinski, B. E. PY - 2012 DA - 2012// TI - Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila Melanogaster JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0038569 DO - 10.1371/journal.pone.0038569 ID - Wang2012 ER - TY - JOUR AU - Zhu, Y. H. AU - Bulavin, D. V. PY - 2012 DA - 2012// TI - Wip1-dependent signaling pathways in health and diseases JO - Prog Mol Biol Transl Sci VL - 106 UR - https://doi.org/10.1016/B978-0-12-396456-4.00001-8 DO - 10.1016/B978-0-12-396456-4.00001-8 ID - Zhu2012 ER - TY - JOUR AU - Park, J. Y. AU - Song, J. Y. AU - Kim, H. M. AU - Han, H. S. AU - Seol, H. S. AU - Jang, S. J. AU - Choi, J. PY - 2012 DA - 2012// TI - p53-independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors JO - Int J Biochem Cell Biol VL - 44 UR - https://doi.org/10.1016/j.biocel.2012.02.013 DO - 10.1016/j.biocel.2012.02.013 ID - Park2012 ER - TY - JOUR AU - Doucette, T. A. AU - Yang, Y. AU - Pedone, C. AU - Kim, J. Y. AU - Dubuc, A. AU - Northcott, P. D. AU - Taylor, M. D. AU - Fults, D. W. AU - Rao, G. PY - 2012 DA - 2012// TI - WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma JO - Neurosurgery. VL - 70 UR - https://doi.org/10.1227/NEU.0b013e31823e5332 DO - 10.1227/NEU.0b013e31823e5332 ID - Doucette2012 ER - TY - JOUR AU - Pandolfi, S. AU - Montagnani, V. AU - Penachioni, J. Y. AU - Vinci, M. C. AU - Olivito, B. AU - Borgognoni, L. AU - Stecca, B. PY - 2013 DA - 2013// TI - WIP1 phosphatase modulates the hedgehog signaling by enhancing GLI1 function JO - Oncogene VL - 32 UR - https://doi.org/10.1038/onc.2012.502 DO - 10.1038/onc.2012.502 ID - Pandolfi2013 ER - TY - JOUR AU - Yavari, A. AU - Nagaraj, R. AU - Owusu-Ansah, E. AU - Folick, A. AU - Ngo, K. AU - Hillman, T. AU - Call, G. AU - Rohatgi, R. AU - Scott, M. P. AU - Banerjee, U. PY - 2010 DA - 2010// TI - Role of lipid metabolism in smoothened derepression in hedgehog signaling JO - Dev Cell VL - 19 UR - https://doi.org/10.1016/j.devcel.2010.06.007 DO - 10.1016/j.devcel.2010.06.007 ID - Yavari2010 ER - TY - JOUR AU - Garcia-Gonzalo, F. R. AU - Phua, S. C. AU - Roberson, E. C. AU - Garcia, G. AU - Abedin, M. AU - Schurmans, S. AU - Inoue, T. AU - Reiter, J. F. PY - 2015 DA - 2015// TI - Phosphoinositides regulate ciliary protein trafficking to modulate hedgehog signaling JO - Dev Cell VL - 34 UR - https://doi.org/10.1016/j.devcel.2015.08.001 DO - 10.1016/j.devcel.2015.08.001 ID - Garcia-Gonzalo2015 ER - TY - JOUR AU - Jacoby, M. AU - Cox, J. J. AU - Gayral, S. AU - Hampshire, D. J. AU - Ayub, M. AU - Blockmans, M. AU - Pernot, E. AU - Kisseleva, M. V. AU - Compere, P. AU - Schiffmann, S. N. PY - 2009 DA - 2009// TI - INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse JO - Nat Genet VL - 41 UR - https://doi.org/10.1038/ng.427 DO - 10.1038/ng.427 ID - Jacoby2009 ER - TY - JOUR AU - Bielas, S. L. AU - Silhavy, J. L. AU - Brancati, F. AU - Kisseleva, M. V. AU - Al-Gazali, L. AU - Sztriha, L. AU - Bayoumi, R. A. AU - Zaki, M. S. AU - Abdel-Aleem, A. AU - Rosti, R. O. PY - 2009 DA - 2009// TI - Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies JO - Nat Genet VL - 41 UR - https://doi.org/10.1038/ng.423 DO - 10.1038/ng.423 ID - Bielas2009 ER - TY - JOUR AU - Mukhopadhyay, S. AU - Wen, X. AU - Ratti, N. AU - Loktev, A. AU - Rangell, L. AU - Scales, S. J. AU - Jackson, P. K. PY - 2013 DA - 2013// TI - The ciliary G-protein-coupled receptor Gpr161 negatively regulates the sonic hedgehog pathway via cAMP signaling JO - Cell VL - 152 UR - https://doi.org/10.1016/j.cell.2012.12.026 DO - 10.1016/j.cell.2012.12.026 ID - Mukhopadhyay2013 ER - TY - JOUR AU - Patterson, V. L. AU - Damrau, C. AU - Paudyal, A. AU - Reeve, B. AU - Grimes, D. T. AU - Stewart, M. E. AU - Williams, D. J. AU - Siggers, P. AU - Greenfield, A. AU - Murdoch, J. N. PY - 2009 DA - 2009// TI - Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the sonic hedgehog pathway JO - Hum Mol Genet VL - 18 UR - https://doi.org/10.1093/hmg/ddp075 DO - 10.1093/hmg/ddp075 ID - Patterson2009 ER - TY - JOUR AU - Mukhopadhyay, S. AU - Wen, X. AU - Chih, B. AU - Nelson, C. D. AU - Lane, W. S. AU - Scales, S. J. AU - Jackson, P. K. PY - 2010 DA - 2010// TI - TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia JO - Genes Dev VL - 24 UR - https://doi.org/10.1101/gad.1966210 DO - 10.1101/gad.1966210 ID - Mukhopadhyay2010 ER - TY - JOUR AU - Norman, R. X. AU - Ko, H. W. AU - Huang, V. AU - Eun, C. M. AU - Abler, L. L. AU - Zhang, Z. AU - Sun, X. AU - Eggenschwiler, J. T. PY - 2009 DA - 2009// TI - Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of hedgehog signaling JO - Hum Mol Genet VL - 18 UR - https://doi.org/10.1093/hmg/ddp113 DO - 10.1093/hmg/ddp113 ID - Norman2009 ER - TY - JOUR AU - Qin, J. AU - Lin, Y. AU - Norman, R. X. AU - Ko, H. W. AU - Eggenschwiler, J. T. PY - 2011 DA - 2011// TI - Intraflagellar transport protein 122 antagonizes sonic hedgehog signaling and controls ciliary localization of pathway components JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1011410108 DO - 10.1073/pnas.1011410108 ID - Qin2011 ER - TY - JOUR AU - Bollen, M. AU - Peti, W. AU - Ragusa, M. J. AU - Beullens, M. PY - 2010 DA - 2010// TI - The extended PP1 toolkit: designed to create specificity JO - Trends Biochem Sci VL - 35 UR - https://doi.org/10.1016/j.tibs.2010.03.002 DO - 10.1016/j.tibs.2010.03.002 ID - Bollen2010 ER - TY - JOUR AU - Hertz, E. P. AU - Kruse, T. AU - Davey, N. E. AU - Lopez-Mendez, B. AU - Sigurethsson, J. O. AU - Montoya, G. AU - Olsen, J. V. AU - Nilsson, J. PY - 2016 DA - 2016// TI - A conserved motif provides binding specificity to the PP2A-B56 phosphatase JO - Mol Cell VL - 63 UR - https://doi.org/10.1016/j.molcel.2016.06.024 DO - 10.1016/j.molcel.2016.06.024 ID - Hertz2016 ER - TY - JOUR AU - Glatter, T. AU - Wepf, A. AU - Aebersold, R. AU - Gstaiger, M. PY - 2009 DA - 2009// TI - An integrated workflow for charting the human interaction proteome: insights into the PP2A system JO - Mol Syst Biol VL - 5 UR - https://doi.org/10.1038/msb.2008.75 DO - 10.1038/msb.2008.75 ID - Glatter2009 ER -