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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling

Fig. 6

AKT inhibitor reduces OGN expression, mTOR activation, and promotes cell death. a OGN cells demonstrate decreased survival upon addition of AKT inhibitor (AKTi) in a time and dose dependent manner. b OGN-expressing meningioma cells demonstrate decreased survival compared to control cells upon addition of 2.5uM AKTi at 48 h and 72 h. c 2.5uM AKTi significantly reduces AKT and mTOR activation, OGN expression, cell cycle marker cyclin B1 expression, and the autophagy inhibitor ULK, while increasing expression of the autophagy marker LC3IIB in OGN cells at 48 h, compared to DMSO treatment. d Decreased cell survival with increased immunoreactivity for the autophagy marker LC3BII in OGN cells treated with 2.5uM AKTi compared to DMSO at 48 h. *p < 0.05, scale bar 50 μm

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Cell Communication and Signaling

ISSN: 1478-811X