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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling

Fig. 4

OGN downregulates NF2. NF2 a mRNA and b protein expression are reduced in OGN-expressing cells, compared to control meningioma cells on qPCR and Western blot analysis, respectively. c Control cells demonstrate more NF2 immunoreactivity compared to OGN cells. *p < 0.05, scale bar 50 μm d Correlation analysis of human meningioma RNA microarray data displays significantly negative correlation of NF2 mRNA to OGN mRNA. e Analysis of human meningiomas reveals increased frequency of NF2 or chr22 loss in samples with higher OGN mRNA expression. f Western blotting analysis of OGN and NF2 protein expression in human meningiomas with intact (WT, wildtype) NF2 or NF2 loss in WHO grade 1 and 2 meningiomas. g Densitometry quantification displays NF2 loss tumors express low NF2 but higher OGN protein

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