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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling

Fig. 1

OGN gene expression is dramatically increased in human meningiomas. a OGN expression is significantly higher in human meningiomas compared to 8 other CNS tumors and normal brain, as detected by microarray, *p < 0.0001. b RNAscope staining reveals OGN mRNA expression across all grades of human meningioma. c RNAscope staining of OGN mRNA across multiple histologic subtypes and grades of human meningioma, scale bar 100 μm, with d optical density quantification. e Western blotting and densitometry analysis of OGN protein expression in multiple meningioma subtypes. CNS, central nervous system; LFC, log fold change; GBM, glioblastoma; OGN, osteoglycin, PNET, primitive neuroectodermal tumor; ATRT, atypical teratoid rhaboid tumor

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Cell Communication and Signaling

ISSN: 1478-811X