Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

Table 1 Cytokine concentrations in the serum of WT, p110γ^−/−, p110δ^−/− and p110γ/δ^−/− mice

	WT		p110γ^−/−		p110δ^−/−		p110γ/δ^−/−		P value
Cytokine [pg/mL]	Mean	SD	Mean	SD	Mean	SD	Mean	SD	p110γ/δ^−/− vs WT	p110γ^−/− vs WT	p110δ^−/− vs WT
IL-1α	61.66	21.76	52.67	8.498	45.91	11.99	57.16	15.99	ns	ns	ns
IL-1β	740.2	104.1	754.9	186.3	609.3	78.74	748.2	157.3	ns	ns	ns
IL-2	85.63	14.55	106.7	34.1	88.36	22	116	36.2	ns	ns	ns
IL-3	62.09	28.82	59.57	23.28	49.09	10.25	65.89	17.22	ns	ns	ns
IL-4	57.3	12.58	60.4	18.53	51.03	9.578	63.23	15.86	ns	ns	ns
IL-5	99.54	18.23	109.1	21.39	97.76	15.41	140	24.72	P < 0.001	ns	ns
IL-6	32.77	3.331	32.01	9.266	28.42	8.041	59.3	49.9	ns	ns	ns
IL-9	1221	333.8	1174	373.5	965.2	275.3	702.9	280.5	P < 0.01	ns	ns
IL-10	202.2	88.91	177.2	71.64	219.1	46.9	270	64.87	ns	ns	ns
IL-12p40	408.1	86.52	294.1	60.73	424.1	70.11	988	346.8	P < 0.001	ns	ns
IL-12p70	428.1	107.1	423.7	108.2	367.7	58.5	459.9	119.2	ns	ns	ns
IL-13	1380	227.7	1426	325	1141	171.2	1250	237.9	ns	ns	ns
IL-17A	339.7	42.02	343	41.05	330.5	45.58	460.6	126.4	P < 0.01	ns	ns
Eotaxin	3300	912.6	4009	1632	2769	954	3215	1206	ns	ns	ns
G-CSF	306.3	91.89	352.9	85.8	268.3	195.9	804.4	610.4	P < 0.01	ns	ns
GM-CSF	744.6	68.77	728.5	151.8	666.9	88.77	709.9	108.6	ns	ns	ns
IFNγ	38.5	7.972	39.27	13.17	30.44	8.659	37.96	18.14	ns	ns	ns
KC	17.48	17.54	52.59	34.61	30.36	23.71	77.14	18.33	P < 0.001	P < 0.05	ns
MCP-1	1243	134.1	1358	284.9	1199	176.9	1572	587.8	ns	ns	ns
MIP-1α	102.7	28.35	93.29	28.18	79.96	24.74	93.43	26.96	ns	ns	ns
MIP-1β	121.4	14.8	134.2	41.05	116.8	22.38	157.8	34.05	ns	ns	ns
MIP-2	35.92	3.688	39.52	8.501	34.94	6.841	50.16	10.04	P < 0.01	ns	ns
RANTES	113.8	17.89	115.9	23.29	112.9	32.27	203.7	88.48	P < 0.01	ns	ns
TNFα	1127	157.2	1127	253.5	1036	124.5	1219	312.8	ns	ns	ns

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