Fig. 3
From: Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract
Developmental hierarchy. (a) Previous model of ISC division. ISCs and EBs are produced through the mitotic activity of Delta+ and esg+ ISCs. The EC and EE fates involve Delta/Notch. (b) New model of ISC division. The EE doublets are generated through ISC symmetric division. ISCs also become EEs directly. See text for details. (c) GsSC lineages. High-Notch GBs are committed progenitors for CC and IC differentiation. However, EEs are derived from low-Notch GBs. (d )RNSC lineages. The MTs consist of the SCs, PCs and RCs. These cells are produced by RNSCs through RBs