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Table 1 Viral targeting of the sumoylation machinery

From: Viral manipulation of the cellular sumoylation machinery

 

Global Sumoylation

SUMO levels

SAE1/SAE2

Ubc9

E3 Ligase

SENPs

PIAS

RanBP2

Mimics

Adeno

  

CELO Gam1 [41, 42]

CELO Gam1 [42];

ADV E1A [46]

ADV E4-ORF3: PIAS3 [64]

 

ADV E1B-55K [83]; ADV E4-ORF3 [110]

ADV pro.? [119]

Hepadna

Herpes

Lytic HSV: decreased [30, 31]

  

HSV [65]

HSV ICP0: PIAS1/3/4 [60, 65, 66]

HSV [70]

  
   

HCMV IE1/2 [50, 54];

HHV-6 IE1/2 [57]

HCMV IE2: PIAS1 [50]

HHV-6? [78,79,80]

  

Latent EBV: increased [35]; Lytic EBV: decreased [32]

EBV LMP1?

 

EBV/KSHV ZTA/RTA [48, 51,52,53, 55, 56];

EBV LMP1 [35]

  

KSHV bKZIP [82];

KSHV LANA [56]

EBV LMP1?

Papilloma

   

HPV E2 [47];

HPV E6 [58]

High risk E6: PIASy [63]

   

Parvo

    

B19 NS1: PIAS3 [61]

   

Polyoma

        

Pox

       

VACV I? [117]

Arena

        

Bunya

    

NP: PIAS1 [67]

   

Calici

        

Corona

        

Flavi

    

HCV: PIAS3? [62]

JEV [69]

  

Filo

    

EBOV VP35: PIAS1 [68]

   

Orthomyxo

IAV/IBV: increased [33, 34]

IAV RNA pol [33]

   

IAV NP? [75]

  

Paramyxo

     

HPIV? [78,79,80]

  

Picorna

     

Entero? [78,79,80]

FMDV Lpro [84, 112]

 

Reo

        

Retro

     

HIV-1 NP [71,72,73,74]

 

HIV [115]

Rhabdo

        

Toga

        
  1. Viral Abbreviations: CELO Chicken embryo lethal orphan, ADV adenovirus, HSV Herpes Simples virus, HCMV human cytomegalovirus, HHV-6 human herpesvirus-6, EBV Epstein-Barr virus, KSHV Kaposi’s Sarcoma-associated herpesvirus, HPV human papilloma virus, VACV Vaccinia virus, HCV hepatitis C virus, JEV Japanese encephalitis virus, EBOV Ebola virus, IAV Influenza A virus, IBV Influenza B virus, HPIV human parainfluenza virus, FMDV foot-and-mouth disease virus, HIV human immunodeficiency virus;? – Probable manipulation