Fig. 4
From: Viral manipulation of the cellular sumoylation machinery
Targeting the SUMO E3 ligases (PIAS Family Members). HSV-1, Parvovirus B19, and possibly hepatitis C virus (HCV) induce the expression of PIAS family members resulting in regulation of inflammation and pathogenesis. ADV and HSV-1 alter the localization of PIAS family members to regulate viral replication. The Ebola virus (EBOV) VP35 protein increases PIAS1 activity to suppress immune responses and promote viral replication. The hantavirus nucleocapsid protein interacts with PIAS1 and PIASxβ, but the function for this interaction is known