Fig. 3
From: Viral manipulation of the cellular sumoylation machinery
Targeting Ubc9. EBV LMP1 hijacks Ubc9 and increases the sumoylation of cellular proteins during latent infections, resulting in the maintenance of latency, oncogenesis, and modulated interferon responses. Human papilloma virus (HPV) E2 protein also hijacks Ubc9 to repress the expression of the viral oncogenes E6 and E7. Conversely, HPV E6 induces the degradation of Ubc9. ADV Gam1 increases the degradation of Ubc9, promoting viral replication. The ADV E1A also interacts with Ubc9 and blocks the poly-sumoylation of proteins