Fig. 3
From: Identification of EGF-NF-κB-FOXC1 signaling axis in basal-like breast cancer
Proposed model of EGF-mediated NFκB-FOXC1 signaling network. The binding of EGF activates the EGFR receptor, leading to downstream activation of Ras-mediated or PI3K-mediated pathways. Activated Ras (Ras-bound GTP) leads to the subsequent phosphorylation and kinase activation sequence of RAF, MEK and ERK, while PI3K phosphorylates PI(4,5)P2 to convert it to PI(3,4,5)P3, which activates Akt. Activation of ERK and Akt leads to the phosphorylation and activation of NF-κB. Phosphorylated NF-κB enters the nucleus where it binds to the promoter region of FOXC1 to up-regulate transcription and protein expression of FOXC1. In our previous study, we have shown that FOXC1 up-regulates NF-κB activity and expression in BLBC cells [24], which ultimately increases cellular proliferation, migration and invasion