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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

Fig. 6

ARC is not regulated by topotecan or UO126. a ClearCa-12 cells were treated with topotecan (10 μg/ml) for 12 h and 24 h. At the protein level (as determined by western blot), no change in ARC expression was observed. b ClearCa-12 cells were treated with the ERK1/2 inhibitor UO126 (50 μM) for 12 and 24 h. This treatment resulted in nearly the complete loss of ERK1/2 phosphorylation. However, no change in ARC expression could be demonstrated on protein level by western blot analysis

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