Table 1 TGFBR2-dependent exosomal proteome of HCT116 MSI tumor cells

 CO3A1_HUMAN

COL3A1

Collagen alpha-1(III) chain

34 47 42

139733

1 0 1

1 0 1

0.8 1.4 0.8

 FAM3C_HUMAN

FAM3C

Protein FAM3C

47 33 52

24950

1 1 1

1 1 1

5.7 5.7 5.7

 GMPR2_HUMAN

GMPR2

GMP reductase 2

49 37 53

38363

0 1 0

0 1 0

8.3 3.4 8.3

 H2A2B_HUMAN

HIST2H2AB

Histone H2A type 2-B

245 261 293 291

13987

8 7 8 9

4 4 4 4

52.3 52.3 52.3 52.3

 INVS_HUMAN

INVS

Inversin

31 36 42

118837

0 2 2

0 1 1

0.6 0.6 0.6

 KPRA_HUMAN

PRPSAP1

Phosphoribosyl pyrophosphate synthase-associated protein 1

39 60 64

39654

1 1 1

1 1 1

6.5 10.4 6.5

 LRC59_HUMAN

LRRC59

Leucine-rich repeat-containing protein 59

32 52 79

35308

1 1 1

1 1 1

3.3 7.2 9.1

 LRRF1_HUMAN

LRRFIP1

Leucine-rich repeat flightless-interacting protein 1

55 37 75

89826

1 1 1

1 1 1

1.5 1.5 3.1

 PCBP3_HUMAN

PCBP3

Poly(rC)-binding protein 3

209 232 212

39725

5 7 7

3 4 4

13.7 17.5 15.4

 RFA2_HUMAN

RPA2

Replication protein A 32 kDa subunit

58 45 94

29342

1 1 2

1 1 2

4.4 4.4 12.6

 SYT5_HUMAN

SYT5

Synaptotagmin-5

50 54 43

43216

1 1 1

1 1 1

1.6 1.6 1.6

 TOM70_HUMAN

TOMM70A

Mitochondrial import receptor subunit TOM70

48 83 53

68096

1 1 1

1 1 1

3 3 3

 U2AF1_HUMAN

U2AF1

Splicing factor U2AF 35 kDa subunit

40 35 51

28368

0 1 1

0 1 1

11.2 3.8 11.2

 ZO1_HUMAN

TJP1

Tight junction protein ZO-1

40 61 83

195682

1 1 1

1 1 1

0.7 1.4 1.4

 B3GN7_HUMAN

B3GNT7

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

30 44 57

46471

0 1 1

0 1 1

4.7 4.7 4.7

 DHE3_HUMAN

GLUD1

Glutamate dehydrogenase 1, mitochondrial

91 60 49

61701

2 1 0

2 1 0

5.9 3.4 3.9

 IL18_HUMAN

IL-18

Interleukin-18

42 44 36

22597

1 1 1

1 1 1

13.5 13.5 13.5

 LOXL4_HUMAN

LOXL4

Lysyl oxidase homolog 4

110 221 169

86425

2 3 3

2 3 3

4.8 9.1 10.3

 UBP6_HUMAN

USP6

Ubiquitin carboxyl-terminal hydrolase 6

34 34 31

160781

1 2 1

1 1 1

0.4 0.4 0.4