Skip to main content
Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling

Fig. 1

Model of oncogenic HH/GLI signaling in AML. Activation of HH/GLI in leukemic (stem) cells of AML patients can be activated by HH ligand derived from adjacent BM stromal cells expressing low levels of the HH inhibitor HHIP. GLI expression in AML cells can enhance radio- and chemoresistance, and promote leukemogenesis by epigenetically repressing cell-cycle inhibitors (e.g. p15) or by synergistic cross-talk with oncogenic FLT3/STAT5 signaling. LIC: leukemia initiating cell; Me: DNA methylation

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X