Table 4 Id gene knockout studies in mice
From: The Id-protein family in developmental and cancer-associated pathways
Deleted gene | Phenotype |
|---|---|
Id1−/− | Decreased neovascularization [146] |
Id2−/− | Lack of Langerhans and splenic dendritic cells, reduced number of NK cells, altered peripheral lymphoid organs [143, 147] |
Id3−/− | Defects in B-cell activation and proliferation upon B-cell receptor signaling, and in both negative and positive selection of T-lineage progenitors [144, 145] |
Id4−/− | Altered brain size, defects in forebrain development [142, 148] |
Id1−/−, Id3−/− | Embryonic lethality with cranial hemorrhage, small brain size, premature neural differentiation [149] |