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Table 3 D-box and NLS/NES motifs of the Id proteins

From: The Id-protein family in developmental and cancer-associated pathways

Id motif

Amino-acid sequence

D-box

 Id1 (126–133)

RAPLSTLN

 Id2 (100–107)

RTPLTTLN

 Id4 (137–144)

RTPLTALN

NES-like

 Id1 (98–109)

VIDYIRDLQLEL

 Id2 (106–115)

LNTDISILSL

NLS-like

 Id1 (74–91)

SRLKELVPTLPQNRKVSK

 Id2 (44–61)

SKLKELVPSIPQNKKVSK

  1. The D-box motifs are recognized by Apc/CCdh1 and trigger Id-protein degradation. The characteristic D-box amino-acid positions are in bold [50]. The NLS/NES motifs regulate the Id-protein nucleo-cytoplasmic shuttling [51, 126, 129]. The hydrophobic residues important for the nuclear export are in bold. The conserved basic positions in the NLS motifs are in bold
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Cell Communication and Signaling

ISSN: 1478-811X